• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Balkan journal of medical genetics: BJMG >THE LRP1 GENE POLYMORPHISM IS ASSOCIATED WITH INCREASED RISK OF METABOLIC SYNDROME PREVALENCE IN THE SERBIAN POPULATION
【24h】

THE LRP1 GENE POLYMORPHISM IS ASSOCIATED WITH INCREASED RISK OF METABOLIC SYNDROME PREVALENCE IN THE SERBIAN POPULATION

机译：LRP1基因多态性与塞尔维亚人群中代谢综合征患病率的风险增加有关

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The determination of genetic background in metabolic syndrome (MetS) represents one of the necessary steps to prevent the disorder, thus reducing the cost of medical treatments and helping to design targeted therapy. The study explores the association between individual alleles of the LRP1 gene and the diagnosis of MetS to find correlation between the low-density lipoprotein receptor-related (LRP1) gene polymorphism and each individual anthropometric and biochemical parameter. The study included 93 males and females, aged from 19 to 65, divided into two groups. The genotype of each person was determined from the restriction fragment length polymorphism-polymerase chain reaction (RFLP-PCR) profile. Results indicated the association of the T allele form of exon 3 LRP1 gene with development and progression of MetS that further pointed out its negative impact on tested anthropometric and biochemical parameters. The presence of the T allele in patients multiplies the chance of occurrence of deviations from the reference values of body mass index (BMI), (4.24-fold) and low-density lipoprotein (LDL) (20.26-fold) compared to C allele carriers. The results showed that T allele presence multiplies the chance (4.76 fold) for the occurrence of MetS in comparison to C allele carriers. Correlation found that the T allele of the LRP1 gene with MetS determinants is not negligible, therefore, the T allele may be considered as a risk factor for MetS development.
机译：代谢综合征（METS）中遗传背景的测定代表了预防疾病的必要步骤之一，从而降低了医疗治疗的成本并有助于设计靶向治疗。该研究探讨了LRP1基因的个体等位基因之间的关联，以及考虑低密度脂蛋白受体相关（LRP1）基因多态性与每个人的人类测量和生物化学参数之间的相关性。该研究包括93名男性和女性，从19至65岁左右，分为两组。从限制性片段长度多态性聚合酶链反应（RFLP-PCR）型材确定每个人的基因型。结果表明，外显子3LRP1基因的T等位基因形式与MET的开发和进展相关，进一步指出其对测试的人体测量和生化参数的负面影响。与C等位基因载体相比，患者中的T等位基因的存在乘以与体重指数（BMI），（4.24倍）和低密度脂蛋白（LDL）（20.26倍）的参考值的偏差发生的可能性。结果表明，与C等位基因载体相比，T等位基因的存在相乘的机会（4.76倍）。相关性发现，LRP1基因与METS决定簇的T等位基因不可忽略不可或缺，因此，T等位基因可能被视为METS发育的危险因素。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号