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首页> 外文期刊>Balkan journal of medical genetics: BJMG >ADRB2 GENE POLYMORPHISMS AND SALBUTAMOL RESPONSIVENESS IN SERBIAN CHILDREN WITH ASTHMA
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ADRB2 GENE POLYMORPHISMS AND SALBUTAMOL RESPONSIVENESS IN SERBIAN CHILDREN WITH ASTHMA

机译：患有哮喘的塞尔维亚儿童的ADRB2基因多态性和Salbutamol反应性

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摘要

Inhaled beta 2 adrenergic receptor (beta 2-AR) agonists are the mainstay of asthma therapy. The beta 2-AR protein is encoded by the ADRB2 gene and variants within this gene can have significant consequences for modulating the response to asthma therapy. This cross-sectional study performed at the University Children's Hospital in Belgrade, included 54 children with asthma. The subjects were genotyped for ADRB2 +46A>G (Arg16Gly, rs1042713) and +79C>G (G1n27G1u, rs1042714) polymorphisms and the association with asthma severity and response to inhaled salbutamol was examined. In Serbian asthmatic children, allele +46A was detected with a frequency of 41.7% and allele +79G was detected with a frequency of 23.1%. Allele +460 was found to be associated with a better response to inhaled salbutamol (p G may be a determinant of asthma severity and response to salbutamol in children with asthma. We did not find any association of +79C>G polymorphisms with the asthma severity and bronchodilator response to inhaled salbutamol. The results of this study can be potentially useful for personalization of asthma treatment.
机译：吸入的β2肾上腺素能受体（β2-Ar）激动剂是哮喘治疗的主要效果。 β2-Ar蛋白由ADRB2基因编码，并且该基因内的变体可能对调节对哮喘疗法的反应产生显着的后果。这种横断面研究在贝尔格莱德大学儿童医院进行，包括54名哮喘的儿童。受试者对ADRB2 + 46A> G（Arg16gly，RS1042713）和+ 79℃g（G1N27G1U，RS1042714）的多态性以及与哮喘严重程度的关联和对吸入沙丁酰胺醇的关系进行基因分型。在塞尔维亚哮喘的儿童中，等位基因+ 46A被检测到41.7％的频率，并且频率为23.1％的等位基因+ 79g。发现等位基因+460与吸入的沙丁胺醇更好的反应有关（P g可以是哮喘儿童哮喘严重程度的决定因素，并且在哮喘的儿童中对沙丁胺醇的反应。我们没有发现任何+ 79c> g多态性与哮喘严重程度的关联和支气管扩张剂对吸入的沙丁胺醇反应。该研究的结果可能对哮喘治疗的个性化有用。

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