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首页> 外文期刊>Cell metabolism >Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut?Microbiota
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Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut?Microbiota

机译：间歇性禁食促进白色脂肪褐变，通过塑造肠道微生物肿块来减少肥胖症

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摘要

Summary While activation of beige thermogenesis is a promising approach for treatment of obesity-associated diseases, there are currently no known pharmacological means of inducing beiging in humans. Intermittent fasting is an effective and natural strategy for weight control, but the mechanism for its efficacy is poorly understood. Here, we show that an every-other-day fasting (EODF) regimen selectively stimulates beige fat development within white adipose tissue and dramatically ameliorates obesity, insulin resistance, and hepatic steatosis. EODF treatment results in a shift in the gut microbiota composition leading to elevation of the fermentation products acetate and lactate and to the selective upregulation of monocarboxylate transporter 1 expression in beige cells. Microbiota-depleted mice are resistance to EODF-induced beiging, while transplantation of the microbiota from EODF-treated mice to microbiota-depleted mice activates beiging and improves metabolic homeostasis. These findings provide a new gut-microbiota-driven?mechanism for activating adipose tissue browning and treating metabolic diseases. Graphical Abstract Display Omitted Highlights ? EODF is a novel strategy for beige adipose development ? EODF selectively induces WAT beiging by reshaping gut microbiota ? EODF reverses high-fat-diet-induced obesity and associated metabolic disorders ? The microbiota-fat axis orchestrates EODF-induced metabolic improvement White adipose beiging is a promising therapy for obesity and related metabolic diseases. Here, Li, Xie and colleagues find that an EODF regimen can selectively induce the beiging of white adipose tissue and subsequently ameliorate metabolic disorders in mice. Gut microbiota orchestrate the effects of EODF on beiging and metabolic improvement.
机译：发明内容在米色热生成的激活是一种有希望的肥胖相关疾病的方法，目前没有已知的人类诱导人类的药理学手段。间歇性禁食是重量控制的有效和自然的策略，但其疗效的机制很差。在这里，我们表明，每隔一天的禁食（EoDF）方案选择性地刺激白色脂肪组织内的米色脂肪发育，并显着改善肥胖，胰岛素抵抗和肝脏脂肪变性。 EODF治疗导致肠道微生物酵母组合物的换档，导致发酵产物的乙酸盐和乳酸乳酸盐和单羧酸盐转运蛋白的选择性上调在米色细胞中的表达。微生物疱疹耗尽的小鼠是对eodf诱导的凸起的抗性，同时将微生物群移植到eodf治疗的小鼠与微生物群耗尽的小鼠激活曲率并改善代谢稳态。这些调查结果提供了一种新的肠道微生物群驱动的机制，用于活化脂肪组织褐变和治疗代谢疾病。图形抽象显示省略了亮点？ Eodf是米色脂肪发育的新战略？ Eodf通过重塑肠道微生物群选择性地诱导Wat凸起？ EODF逆转高脂饮食诱导的肥胖症和相关的代谢障碍吗？微生物脂肪轴协调eodf诱导的代谢改善白色脂肪露曲是肥胖症和相关代谢疾病的有希望的治疗。在这里，李，谢和同事发现，eodf方案可以选择性地诱导白色脂肪组织的凸起，随后在小鼠中改善代谢紊乱。 Gut Microbiota协调eodf对露天的影响和代谢改进。

著录项

  • 来源
    《Cell metabolism》 |2017年第4期|共14页
  • 作者

    Guolin Li; Cen Xie; Siyu Lu; Robert G. Nichols; Yuan Tian; Licen Li; Daxeshkumar Patel; Yinyan Ma; Chad N. Brocker; Tingting Yan; Kristopher W. Krausz; Rong Xiang; Oksana Gavrilova; Andrew D. Patterson; Frank J. Gonzalez;

  • 作者单位

    Laboratory of Metabolism Center for Cancer Research National Cancer Institute National;

    Laboratory of Metabolism Center for Cancer Research National Cancer Institute National;

    The Key Laboratory of Protein Chemistry and Developmental Biology of Ministry of Education College;

    Department of Molecular Toxicology The Pennsylvania State University;

    Department of Molecular Toxicology The Pennsylvania State University;

    The Key Laboratory of Protein Chemistry and Developmental Biology of Ministry of Education College;

    Laboratory of Metabolism Center for Cancer Research National Cancer Institute National;

    Mouse Metabolism Core Laboratory National Institute of Diabetes and Digestive and Kidney Diseases;

    Laboratory of Metabolism Center for Cancer Research National Cancer Institute National;

    Laboratory of Metabolism Center for Cancer Research National Cancer Institute National;

    Laboratory of Metabolism Center for Cancer Research National Cancer Institute National;

    The State Key Laboratory of Medical Genetics &

    School of Life Sciences Central South University;

    Mouse Metabolism Core Laboratory National Institute of Diabetes and Digestive and Kidney Diseases;

    Department of Molecular Toxicology The Pennsylvania State University;

    Laboratory of Metabolism Center for Cancer Research National Cancer Institute National;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 内分泌腺疾病及代谢病;
  • 关键词

    intermittent fasting; every-other-day fasting (EODF); browning; beige adipocytes; gut microbiota; short-chain fatty acid; metabolic syndrome; obesity;

    机译：间歇性禁食;每隔一天的禁食（EODF）;褐变;米色adipocytes;肠道微生物酵母;短链脂肪酸;代谢综合征;肥胖;

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