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Metabolic Flexibility in Health and Disease

机译：健康与疾病的代谢灵活性

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Metabolic flexibility is the ability to respond or adapt to conditional changes in metabolic demand. This broad concept has been propagated to explain insulin resistance and mechanisms governing fuel selection between glucose and fatty acids, highlighting the metabolic inflexibility of obesity and type 2 diabetes. In parallel, contemporary exercise physiology research has helped to identify potential mechanisms underlying altered fuel metabolism in obesity and diabetes. Advances in "omics'' technologies have further stimulated additional basic and clinical-translational research to further interrogate mechanisms for improved metabolic flexibility in skeletal muscle and adipose tissue with the goal of preventing and treating metabolic disease.
机译：代谢灵活性是能够响应或适应代谢需求的条件变化。 这种广泛的概念已经繁殖，以解释胰岛素抵抗和机制治疗葡萄糖和脂肪酸之间的燃料选择，突出了肥胖和2型糖尿病的代谢屈虑率。 同时，当代运动生理学研究有助于识别肥胖症和糖尿病中改变燃料代谢的潜在机制。 “OMICS”技术的进步进一步刺激了额外的基本和临床翻译研究，以进一步询问骨骼肌中的代谢柔韧性和脂肪组织的进一步询问机制，其目的是预防和治疗代谢疾病。

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