High Cholesterol at the Heart of Phagolysosomal Damage

Lieberman Andrew P.; Swanson Joel A.

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High Cholesterol at the Heart of Phagolysosomal Damage

机译：吞噬骨髓损伤的核心高胆固醇

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Phagolysosome membrane rupture can trigger a maladaptive immune response that promotes tissue damage. In Science, Cantuti-Castelvetri et al. (2018) report that cholesterol-rich myelin debris overwhelms reverse cholesterol transport in aged phagocytes, leading to cholesterol crystal formation, damaged phagolysosomes, and limited tissue repair.

机译：植物质膜破裂可以引发促进组织损伤的不良免疫应答。科学，Cantuti-Castelvetri等。（2018）报告富含胆固醇的髓鞘碎片压倒性吞噬细胞的逆转胆固醇转运，导致胆固醇晶体形成，受损的吞噬细胞和有限的组织修复。

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《Cell metabolism》 |2018年第3期|共2页
作者
Lieberman Andrew P.; Swanson Joel A.;
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作者单位

Univ Michigan Sch Med Dept Pathol Ann Arbor MI 48109 USA;

Univ Michigan Sch Med Dept Microbiol &

Immunol Ann Arbor MI 48109 USA;

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正文语种 eng
中图分类内分泌腺疾病及代谢病;
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1. High Cholesterol at the Heart of Phagolysosomal Damage [J] . Lieberman Andrew P., Swanson Joel A. Cell metabolism . 2018,第3期

机译：在吞噬细胞骨髓损伤的核心高胆固醇
2. Glucomannan or Glucomannan Plus Spirulina-Enriched Squid-Surimi Diets Reduce Histological Damage to Liver and Heart in Zucker fa/fa Rats Fed a Cholesterol-Enriched and Non-Cholesterol-Enriched Atherogenic Diet [J] . Vazquez-Velasco Miguel, Gonzalez-Torres Laura, Garcia-Fernandez Rosa A., Journal of medicinal food . 2017,第6期

机译：葡甘露霉甘油或葡糖胺类富含螺旋藻鱿鱼毒素饮食减少了Zucker Fa / FA大鼠肝脏和心脏的组织学损伤，喂养富含胆固醇和富含胆固醇的致动脉粥样饮食
3. Zebra blenny protein hydrolysates as a source of bioactive peptides with prevention effect against oxidative dysfunctions and DNA damage in heart tissues of rats fed a cholesterol-rich diet [J] . Ktari Naourez, Bkhairia Intidhar, Nasri Rim, Food research international . 2017,第pta1期

机译：斑马软蛋白蛋白质水解物为生物活性肽的来源，对富含胆固醇饮食的大鼠心脏组织的氧化功能障碍和DNA损伤具有预防作用
4. The Correlation between Dietary Fats Intake with Total Cholesterol and Triglycerides Levels in Patients with Coronary Heart Disease [C] . Rista Nugraheni, Zainal Arifin Adnan, Adi Magna Patriadi Nuhriawangsa International Conference on Biology and Applied Science . 2019

机译：冠心病患者中膳食脂肪脂肪脂肪脂肪酸和甘油三酯水平的相关性
5. SERUM HIGH DENSITY LIPOPROTEIN CHOLESTEROL AND TOTAL CHOLESTEROL LEVELS AND OTHER CORONARY HEART DISEASE RISK FACTORS IN RURAL (PREDOMINANTLY AMISH) VERSUS URBAN POPULATIONS [D] . LONDON, CAROLE PAMELA. 1982

机译：农村（主要为阿米什族人）与城市人口的血清高密度脂蛋白胆固醇和总胆固醇水平以及其他冠状动脉疾病的危险因素
6. Renitence vacuoles facilitate protection against phagolysosomal damage in activated macrophages [O] . Amanda O. Wong, Matangi Marthi, Zachary I. Mendel, 2018

机译：再生液泡有助于保护巨噬细胞免于吞噬体的破坏
7. Beyond Low-Density Lipoprotein Cholesterol Respective Contributions of Non-High-Density Lipoprotein Cholesterol Levels, Triglycerides, and the Total Cholesterol/High-Density Lipoprotein Cholesterol Ratio to Coronary Heart Disease Risk in Apparently Healthy Men and Women [O] . Arsenault, Benoit J., Rana, Jamal S., Stroes, Erik S. G., 2009

机译：除了低密度脂蛋白胆固醇以外，显然健康男女的非高密度脂蛋白胆固醇水平，甘油三酸酯和总胆固醇/高密度脂蛋白胆固醇比对冠心病风险的贡献
8. National Cholesterol Education Program. Live Healthier, Live Longer: Lowering Cholesterol for the Person with Heart Disease [R] . 1996

机译：国家胆固醇教育计划。活得更健康，更长寿：降低患有心脏病的人的胆固醇

High Cholesterol at the Heart of Phagolysosomal Damage

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