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首页> 外文期刊>Cell biology international. >Mesenchymal stem cells derived from different origins have unique sensitivities to different chemotherapeutic agents
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Mesenchymal stem cells derived from different origins have unique sensitivities to different chemotherapeutic agents

机译：来自不同起源的间充质干细胞对不同的化学治疗剂具有独特的敏感性

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摘要

BMSCs (bone-marrow-derived mesenchymal stem cells) and ADSCs (adipose tissue-derived mesenchymal stem cells) are virtually identical in cell surface marker profile and differentiation potential. These cell populations have promising characteristics for clinical application. We have investigated the sensitivity of these cell populations to various chemotherapeutic agents by testing the inhibition of cell proliferation, low molecular DNA bands formation, in situ apoptosis, apoptosis-related gene expression and cell senescence after treatment. BU (busulfan), methotrexate and doxorubicin treatment led to a marked and dose-dependent reduction in cell viability compared with 5-FU (5-fluorouracil) treatment. Different expression patterns of apoptosis-related genes were found in the BMSCs and ADSCs following treatment with the agents, but no low molecular mass DNA bands were detected. BMSCs had a higher percentage of apoptotic and senescent cells following treatment with chemotherapeutic agents compared with ADSCs. These findings suggest that these two cell populations respond differently to chemotherapy treatment. ADSCs are more resistant than BMSCs to chemotherapy-induced senescence and apoptosis, indicating that they might be more advantageous to use in the clinic than BMSCs.
机译：BMSCs（骨髓衍生的间充质干细胞）和ADSCs（脂肪组织衍生的间充质干细胞）在细胞表面标记曲线和分化电位中几乎相同。这些细胞群具有临床应用的有希望的特征。我们通过测试细胞增殖，低分子DNA条带形成，原位凋亡，治疗后的细胞凋亡相关基因表达和细胞衰老，研究了这些细胞群对各种化学治疗剂的敏感性。与5-fu（5-氟尿嘧啶）处理相比，Bu（Busulfan），甲氨蝶呤和多柔比蛋白治疗导致细胞活力的显着和剂量依赖性降低。在用试剂处理后，在BMSC和ADSC中发现不同的表达相关基因的表达模式，但没有检测到低分子量DNA带。与ADSC相比，通过化学治疗剂处理后，BMSCs具有更高的凋亡和衰老细胞。这些发现表明，这两个细胞种群对化疗治疗不同。 ADSCs比BMSCs更耐受化疗诱导的衰老和凋亡，表明它们可能比BMSC在临床上更有利。

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