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首页> 外文期刊>Cell biology international. >Consideration of dual characters of exosomes in the tumour immune response.
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Consideration of dual characters of exosomes in the tumour immune response.

机译：肿瘤免疫应答中外虫物体的双重特征的考虑。

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Efforts to get a strong and sustained anti-tumour immune response induced by a tumour specific antigen have failed, but sipuleucel-T has been approved by the US Food and Drug Administration (FDA). We noticed that exosomes secreted by tumour cells or immune cells may be crucially involved in the tumour immune response, whereas others have had inconsistent findings on exosome involvement. Based on immune network theory, we summarise research advances of exosomes and speculate that in the tumour immune response exosomes follow the immune response curve hypothesis. Exosomes activate simultabeously both immune activation and immune tolerance, but at different intensities. To obtain a desired anti-immune response, the initial point of immunity should be determined to achieve the strongest anti-tumour response, and repeated in vitro to extend and enhance this response. As a result, our hypothesis proposes that studies should now be directed at determining the exact time of exosome activity in maintaining a viable anti-tumour immune response in vivo.
机译：通过肿瘤特异性抗原引起的强烈和持续的抗肿瘤免疫应答的努力失败，但SipuEucel-T已被美国食品和药物管理局（FDA）批准。我们注意到，肿瘤细胞或免疫细胞分泌的外泌体可能是至关重要的肿瘤免疫应答，而其他物质对外来体组的参与具有不一致的结果。基于免疫网络理论，我们总结了外来体的研究进展，并推测，在肿瘤免疫反应外，外来遵循免疫应答曲线假设。外泌体同时激活免疫激活和免疫耐受，但在不同的强度下。为了获得所需的抗免疫应答，应确定初始免疫点以达到最强的抗肿瘤反应，并重复体外延伸和增强这种反应。因此，我们的假设提出了现在应该针对确定在体内维持活性抗肿瘤免疫应答的外部活动的确切时间。

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