delta-Catenin interacts with LEF-1 and negatively regulates its transcriptional activity

He Yongfeng; Ki Hyunkyoung; Kim Hangun; Kim Kwonseop

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delta-Catenin interacts with LEF-1 and negatively regulates its transcriptional activity

机译：Delta-catenin与Lef-1相互作用，负面调节其转录活动

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delta-Catenin and beta-catenin belong to different subfamilies of armadillo proteins but share some common binding partners, such as E-cadherin. This is the first study that demonstrated a novel common binding partner for delta-catenin and beta-catenin, lymphoid enhancer factor-1 (LEF-1). We found that the N-terminus of delta-catenin (amino acids 85-325) bound to the middle region of LEF-1 unlike beta-catenin. Overexpressed delta-catenin entered the nucleus and inhibited LEF-1-mediated transcriptional activity in Bosc23 and DLD-1 cell lines. The current study provided novel insights that will provide a better understanding of the effects of beta-catenin on Wnt/LEF-1-mediated transcriptional activity.

机译：Delta-catenin和Beta-catenin属于犰狳蛋白的不同亚属，但分享一些常见的结合伴侣，例如e-cadherin。这是第一项研究表明δ-catenin和β-连环蛋白，淋巴增强剂因子-1（LEF-1）的新型常见结合配偶体。我们发现与β-catenin不同于Lef-1的中间区域的δ-连环蛋白（氨基酸85-325）的N-末端。过表达δ-catenin进入核，并抑制BOSC23和DLD-1细胞系中的LEF-1介导的转录活性。目前的研究提供了新颖的见解，可以更好地了解β-连环蛋白对Wnt / Lef-1介导的转录活性的影响。

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来源
《Cell biology international.》 |2015年第8期|共8页
作者
He Yongfeng; Ki Hyunkyoung; Kim Hangun; Kim Kwonseop;
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作者单位

Chonnam Natl Univ Coll Pharm Gwangju 500757 South Korea;

Chonnam Natl Univ Coll Pharm Gwangju 500757 South Korea;

Sunchon Natl Univ Coll Pharm Sunchon 540950 South Korea;

Chonnam Natl Univ Coll Pharm Gwangju 500757 South Korea;

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原文格式 PDF
正文语种 eng
中图分类细胞生物学;
关键词
delta-catenin; LEF-1; beta-catenin;

机译：delta-catenin;lef-1;beta-catenin;

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1. delta-Catenin interacts with LEF-1 and negatively regulates its transcriptional activity [J] . He Yongfeng, Ki Hyunkyoung, Kim Hangun, Cell biology international. . 2015,第8期

机译：δ-连环蛋白与LEF-1相互作用并负面调节其转录活性
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delta-Catenin interacts with LEF-1 and negatively regulates its transcriptional activity

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