Micro-RNAs (miRNAs): genomic organisation, biogenesis and mode of action.

Mahboob Ul Hussain

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Micro-RNAs (miRNAs): genomic organisation, biogenesis and mode of action.

机译：微rnas（miRNA）：基因组组织，生物生成和行动方式。

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MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression in animals and in plants. In recent years, miRNAs have been shown to be important biological molecules for regulating various cellular functions. miRNAs function post-transcriptionally usually by base-pairing to the mRNA 3'-untranslated regions of the mRNAs and repress protein synthesis by mechanisms that are not fully understood. Various miRNA genes have been mapped in the genome of a number of organisms and the list continues to grow. Details regarding the genomic organisation, transcriptional regulation and post-transcriptional maturation of miRNAs are still emerging. In this review, information regarding the genomic organisation, biogenesis and regulation of expression of miRNAs is discussed.

机译：microRNAs（miRNA）是小型非编码RNA，其调节动物和植物中的基因表达。近年来，MIRNA已被证明是用于调节各种细胞功能的重要生物分子。 MiRNA函数通常通过碱基对MRNA 3'-未翻译的MRNA的碱基进行配对，并通过不完全理解的机制抑制蛋白质合成。在许多生物的基因组中映射了各种miRNA基因，并且该列表继续生长。关于基因组组织，转录调控和miRNA后转录成熟的细节仍在出现。在本次综述中，讨论了有关基因组组织，生物发生和MiRNA表达的调控的信息。

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《Cell and Tissue Research》 |2012年第2期|共9页
作者
Mahboob Ul Hussain;
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作者单位

Department of Biotechnology University of Kashmir Science Block Hazratbal Campus Srinagar;

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原文格式 PDF
正文语种 eng
中图分类细胞生物学;
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1. Micro-RNAs (miRNAs): genomic organisation, biogenesis and mode of action. [J] . Mahboob Ul Hussain Cell and Tissue Research . 2012,第2期

机译：微小RNA（miRNA）：基因组组织，生物发生和作用方式。
2. miRNAs: their discovery, biogenesis and mechanism of action. [J] . N Tétreault, V De Guire Clinical Biochemistry . 2013,第10a11期

机译：miRNA：它们的发现，生物发生和作用机理。
3. Identification of precursor transcripts for 6 novel miRNAs expands the diversity on the genomic organisation and expression of miRNA genes in rice [J] . Séverine Lacombe, Hiroshi Nagasaki, Carole Santi, BMC Plant Biology . 2008,第1期

机译：鉴定6种新型miRNA的前体转录本可扩大水稻中miRNA基因组的组织和表达的多样性
4. Deriving Object-based Business Process Architectures Using Role-based Business Process Models: A Reverse-Engineering Approach Applied to the Cell Therapy and Applied Genomics in a Cancer Care Organisation [C] . Dina Tbaishat, Yousra Odeh, Abdelghani Tbakhi, International Conference on Cancer Care Informatics . 2018

机译：使用基于角色的业务流程模型推导基于对象的业务流程体系结构：一种逆向工程方法，应用于癌症护理组织的细胞治疗和应用基因组学
5. Functional Deficiency of Dicer in Atherosclerosis: A Role for Hemodynamic Shear Stress Regulation of the miRNA Biogenesis Pathway [D] . Tran, Eileen. 2019

机译：动脉粥样硬化中的Dicer功能缺乏：miRNA生物发生途径的血流动力剪切应力调节作用
6. Identification of precursor transcripts for 6 novel miRNAs expands the diversity on the genomic organisation and expression of miRNA genes in rice [O] . Séverine Lacombe, Hiroshi Nagasaki, Carole Santi, 2008

机译：鉴定6种新型miRNA的前体转录本可扩大水稻中miRNA基因组的组织和表达的多样性
7. Identification of precursor transcripts for 6 novel miRNAs expands the diversity on the genomic organisation and expression of miRNA genes in rice [O] . 2008

机译：鉴定6种新型miRNA的前体转录本可扩大水稻中miRNA基因组的组织和表达的多样性

Micro-RNAs (miRNAs): genomic organisation, biogenesis and mode of action.

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