...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cell and Tissue Research >Spontaneous regression of neuroblastoma
【24h】

Spontaneous regression of neuroblastoma

机译：神经母细胞瘤的自发性回归

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Neuroblastomas are characterized by heterogeneous clinical behavior, from spontaneous regression or differentiation into a benign ganglioneuroma, to relentless progression despite aggressive, multimodality therapy. Indeed, neuroblastoma is unique among human cancers in terms of its propensity to undergo spontaneous regression. The strongest evidence for this comes from the mass screening studies conducted in Japan, North America and Europe and it is most evident in infants with stage 4S disease. This propensity is associated with a pattern of genomic change characterized by whole chromosome gains rather than segmental chromosome changes but the mechanism(s) underlying spontaneous regression are currently a matter of speculation. There is evidence to support several possible mechanisms of spontaneous regression in neuroblastomas: (1) neurotrophin deprivation, (2) loss of telomerase activity, (3) humoral or cellular immunity and (4) alterations in epigenetic regulation and possibly other mechanisms. It is likely that a better understanding of the mechanisms of spontaneous regression will help to identify targeted therapeutic approaches for these tumors. The most easily targeted mechanism is the delayed activation of developmentally programmed cell death regulated by the tropomyosin receptor kinase A (TrkA) pathway. Pan-Trk inhibitors are currently in clinical trials and so Trk inhibition might be used as the first line of therapy in infants with biologically favorable tumors that require treatment. Alternative approaches consist of breaking immune tolerance to tumor antigens but approaches to telomere shortening or epigenetic regulation are not easily druggable. The different mechanisms of spontaneous neuroblastoma regression are reviewed here, along with possible therapeutic approaches.
机译：神经母细胞瘤的特征在于异质临床行为，从自发的回归或分化成良性甘蓝瘤，尽管有侵略性的多层疗法，但仍然具有无情的进展。实际上，神经母细胞瘤在人类癌症中是独一无二的，其在其经历自发回归的倾向方面。最强大的证据来自日本，北美和欧洲的大规模筛查研究，它在4S阶段疾病中最明显。这种倾向与由整个染色体增益而不是节段性染色体变化的基因组变化模式相关，但是自发性回归的机制目前是一种猜测问题。有证据表明在神经细胞组织中支持几种可能的自发性回归机制：（1）神经营养蛋白剥夺，（2）端粒酶活性的丧失，（3）静脉曲张或细胞免疫和（4）表观遗传调节和可能的其他机制。更好地了解自发回归机制将有助于识别这些肿瘤的有针对性的治疗方法。最容易有针对性的机制是由对冠状阴性素受体激酶A（Trka）途径调节的发育编程细胞死亡的延迟激活。 Pan-Trk抑制剂目前处于临床试验中，因此TRK抑制可能被用作具有治疗的生物良好肿瘤的婴儿的第一线治疗。替代方法包括破坏肿瘤抗原的免疫耐受，但端粒缩短或表观遗传调节的方法不易耐用。这里综述了自发神经母细胞瘤回归的不同机制，以及可能的治疗方法。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号