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首页> 外文期刊>Cell and Tissue Research >Afferent nerve fibres in the wall of the rat urinary bladder
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Afferent nerve fibres in the wall of the rat urinary bladder

机译：大鼠膀胱壁中的传入神经纤维

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Structure and distribution of afferent nerve fibres in the rat bladder were studied by fluorescence microscopy after selective staining with antibodies against neuropeptide CGRP. Afferent fibres are very abundant (by comparison with other viscera) and interconnected in all bladder parts: muscle, urothelium, connective tissue, blood vessels, serosa. Their highest concentration is beneath the urothelium in equatorial and caudal regions, where they form a plexus, while individually maintaining a tree-like structure with innumerable branches running without preferential orientation. In cranial regions, mucosal afferent fibres become rare or absent. Abundant fibres are found in the detrusor, within each muscle bundle, with long strings of varicosities parallel to muscle cells. Afferent fibres, invariably varicose over hundreds of micrometres of their terminal parts and while still branching, comprise chains of hundreds of varicosities. Varicosities are irregular in size, frequency and separation, without specialised terminal structures around them, or within or around the fibre's ending. The possibility that varicosities are transduction points for sensory inputs is discussed, with the implication of a process taking place over considerable length in each branch of each fibre. Interconnectedness of afferent nerves of various bladder tissues, distribution of varicosities over hundreds of micrometres along axonal branches, absence of clear target structures for the fibres, apparent irregularity in the size and sequence of varicosities suggest an innervation that is not rigidly wired with distinct sensory pathways. In fact, the structural evidence suggests extensive afferent integration at the periphery, with wide distribution of source points and broad range of physical detectors.
机译：通过荧光显微镜用抗神经肽CGRP选择染色后，通过荧光显微镜研究了大鼠膀胱中传入神经纤维的结构和分布。传入的纤维非常丰富（与其他内脏的比较）并在所有膀胱零件中相互连接：肌肉，尿路鞘，结缔组织，血管，血清。它们的最高浓度是赤道和尾部区域的尿路鞘，它们形成丛，同时单独维持与无数分支的树状结构，无需优先定位。在颅骨区域中，粘膜传入纤维变得稀有或不存在。在每个肌肉束内的肉排器中发现丰富的纤维，并且长时间的粉丝平行于肌肉细胞。传入的纤维，在其终端的数百微米的终端部分和仍然分枝上的数百微米上致敏，包括数百种致差的链。含有不规则的尺寸，频率和分离，无需围绕它们的专用终端结构，或在光纤的结束内或周围。讨论了甲状变性的可能性是讨论了感觉输入的转导点，在每个光纤的每个分支中发生了在相当长的长度上发生的过程的含义。各种膀胱组织的互连，沿着轴突分裂的数百微米分布，纤维的透明靶结构的分布，尺寸和官能序列的表观不规则性表明了一种不刚性的感觉途径刚性连接的支护。事实上，结构证据表明，在外围方面的广泛传育集成，源点广泛分布和广泛的物理探测器。

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