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首页> 外文期刊>Cellular immunology >Total glucosides of paeony inhibits Th1/Th17 cells via decreasing dendritic cells activation in rheumatoid arthritis
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Total glucosides of paeony inhibits Th1/Th17 cells via decreasing dendritic cells activation in rheumatoid arthritis

机译：芍药苷通过减少类风湿性关节炎中的树突细胞活化来抑制TH1 / TH17细胞

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摘要

Total glucoside of paeony (TGP), an active compound extracted from paeony root, has been used in therapy for rheumatoid arthritis (RA). Th1 and Th17 cells are now believed to play crucial roles in the lesions of RA. However, the molecular mechanism of TGP in inhibition of Th1 and Th17 cells remains unclear. In this study, we found that TGP treatment significantly decreased percentage and number of Th1 and Th17 cells in collagen induced arthritis (CIA) mice. Consistently, treatment with TGP decreased expression of T-bet and ROR gamma t as well as phosphorylation of STAT1 and STAT3. In particular, TGP treatment inhibited dendritic cells (DCs) maturation and reduced production of IL-12 and IL-6. Moreover, TGP-treatment RA patients showed shank population of matured DCs and IFN-gamma-, IL-17-producing cells. Taken together, our results demonstrated that TGP inhibited maturation and activation of DCs, which led to impaired Th1 and Th17 differentiation in vivo. (C) 2013 Elsevier Inc. All rights reserved.
机译：芍药苷（TGP）的​​总葡萄糖苷，一种从芍药根的活性化合物，已用于类风湿性关节炎（RA）治疗。现在认为Th1和Th17细胞在Ra的病变中起着至关重要的作用。然而，TGP在抑制Th1和Th17细胞中的分子机制仍不清楚。在这项研究中，我们发现TGP治疗显着降低了胶原蛋白诱导的关节炎（CIA）小鼠的Th1和Th17细胞的百分比和数量。始终如一地，TGP的处理减少了T-BET和RORγT的表达以及STAT1和Stat3的磷酸化。特别地，TGP处理抑制树突细胞（DCS）成熟并降低IL-12和IL-6的产生。此外，TGP治疗RA患者显示出成熟的DC和IFN-Gamma-，IL-17产生细胞的柄群。在一起，我们的结果表明TGP抑制DCS的成熟和激活，其导致体内损害和Th17分化。 （c）2013年Elsevier Inc.保留所有权利。

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  • 来源
    《Cellular immunology》 |2012年第2期|共8页
  • 作者

    Lin Jinpiao; Xiao Lianbo; Ouyang Guilin; Shen Yu; Huo Rongfen; Zhou Zhou; Sun Yue; Zhu Xianjin; Zhang Jie; Shen Baihua; Li Ningli;

  • 作者单位

    Shanghai Jiao Tong Univ Sch Med Shanghai Inst Immunol Inst Med Sci Shanghai 200025 Peoples R;

    Guanghua Rheumatol Hosp Shanghai Peoples R China;

    Guanghua Rheumatol Hosp Shanghai Peoples R China;

    Guanghua Rheumatol Hosp Shanghai Peoples R China;

    Shanghai Jiao Tong Univ Sch Med Shanghai Inst Immunol Inst Med Sci Shanghai 200025 Peoples R;

    Shanghai Jiao Tong Univ Sch Med Shanghai Inst Immunol Inst Med Sci Shanghai 200025 Peoples R;

    Shanghai Jiao Tong Univ Sch Med Shanghai Inst Immunol Inst Med Sci Shanghai 200025 Peoples R;

    Shanghai Jiao Tong Univ Sch Med Shanghai Inst Immunol Inst Med Sci Shanghai 200025 Peoples R;

    Shanghai Jiao Tong Univ Sch Med Shanghai Inst Immunol Inst Med Sci Shanghai 200025 Peoples R;

    Shanghai Jiao Tong Univ Sch Med Shanghai Inst Immunol Inst Med Sci Shanghai 200025 Peoples R;

    Shanghai Jiao Tong Univ Sch Med Shanghai Inst Immunol Inst Med Sci Shanghai 200025 Peoples R;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 细胞生物学;
  • 关键词

    Total glucosides of paeony; Th1/Th17 cells; Dendritic cells; Maturation; Rheumatoid arthritis;

    机译：芍药苷的总葡萄糖苷;th1 / th17细胞;树突状细胞;成熟;类风湿性关节炎;

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