...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cell cycle >LINP1 facilitates DNA damage repair through non-homologous end joining (NHEJ) pathway and subsequently decreases the sensitivity of cervical cancer cells to ionizing radiation
【24h】

LINP1 facilitates DNA damage repair through non-homologous end joining (NHEJ) pathway and subsequently decreases the sensitivity of cervical cancer cells to ionizing radiation

机译：LINP1通过非同源终端连接（NHEJ）途径促进DNA损伤修复，随后降低宫颈癌细胞对电离辐射的敏感性

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

LncRNA in non-homologous end joining (NHEJ) pathway 1 (LINP1) is an lncRNA which promotes therapeutic resistance in triple-negative breast cancer (TNBC). However, the expression and function of LINP1 in cervical cancer is not yet well-understood. In this study, we evaluated the expression levels of LINP1 in tumor tissues and cell lines of cervical cancer. We found that LINP1 associates with NHEJ proteins (Ku80 and DNA-PKcs). LINP1 translocates from cytosol to nucleus in response to irradiation. In addition, LINP1 knockdown significantly increases the levels of cleaved caspase3 and PARP, leading to enhanced cell apoptosis after ionizing radiation (IR). LINP1-knockdown cells showed delayed repairs of DNA double-strand breaks (DSBs) after IR. Finally, LINP1 knockdown increases radiosensitivity of Hela S3 cells. These results suggest that LINP1 facilitates DSBs repair through NHEJ pathway and may thus serve as a prognostic marker and a potential target for the therapy of cervical cancer.
机译：在非同源末端接合（NHEJ）途径1（LINP1）中的LNCRNA是促进三阴性乳腺癌（TNBC）中治疗性的LNCRNA。 然而，LINP1在宫颈癌中的表达和功能尚未理解。 在这项研究中，我们评估了宫颈癌肿瘤组织和细胞系中LINP1的表达水平。 我们发现LINP1与NHEJ蛋白（KU80和DNA-PKCS）相关联。 LINP1响应于照射，从Cytosol转向核。 此外，LINP1敲低显着增加了切割的CASPase3和PARP的水平，导致电离辐射（IR）后的细胞凋亡。 LINP1-敲低细胞显示IR后DNA双链断裂（DSB）的延迟修复。 最后，LINP1敲低增加了HELA S3细胞的放射敏感性。 这些结果表明LINP1通过NHEJ途径促进DSB修复，因此可以作为预后标志物和宫颈癌治疗的潜在靶标。

著录项

  • 来源
    《Cell cycle》 |2018年第4期|共9页
  • 作者

    Wang Xuanxuan; Liu Hai; Shi Liming; Yu Xiaoli; Gu Yanjun; Sun Xiaonan;

  • 作者单位

    Zhejiang Univ Sch Med Sir Run Run Shaw Hosp Dept Radiat Oncol 3 Qingchun East Rd Hangzhou;

    Zhejiang Univ Sch Med Sir Run Run Shaw Hosp Dept Radiat Oncol 3 Qingchun East Rd Hangzhou;

    Zhejiang Univ Sch Med Sir Run Run Shaw Hosp Dept Radiat Oncol 3 Qingchun East Rd Hangzhou;

    Zhejiang Univ Sch Med Sir Run Run Shaw Hosp Dept Pathol Hangzhou Zhejiang Peoples R China;

    Zhejiang Univ Sch Med Sir Run Run Shaw Hosp Dept Radiat Oncol 3 Qingchun East Rd Hangzhou;

    Zhejiang Univ Sch Med Sir Run Run Shaw Hosp Dept Radiat Oncol 3 Qingchun East Rd Hangzhou;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 细胞生物学;
  • 关键词

    LINP1; long non-coding RNA; cervical cancer; radiotherapy; radiation resistance;

    机译：LINP1;长期非编码RNA;宫颈癌;放射疗法;辐射抗性;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号