Phospholipase D1 is a regulator of platelet-mediated inflammation

Klier Meike; Gowert Nina Sarah; Jaeckel Sven; Reinhardt Christoph; Elvers Margitta

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Phospholipase D1 is a regulator of platelet-mediated inflammation

机译：磷脂酶D1是血小板介导的炎症的调节剂

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Glycoprotein (GP)Ib is not only required for stable thrombus formation but for platelet-mediated inflammatory responses. Phospholipase (PL)D1 is essential for GPIb-dependent aggregate formation under high shear conditions while nothing is known about PLD1-induced regulation of GPIb in platelet-mediated inflammation and the underlying mechanisms. This study aimed to investigate the relevance of PLD1 for platelet-mediated endothelial and leukocyte recruitment and activation in vitro and in vivo.

机译：糖蛋白（GP）IB不仅需要稳定的血栓形成，而且仅用于血小板介导的炎症反应。磷脂酶（PL）D1对于在高剪切条件下GPIB依赖性聚集体形成是必不可少的，而在血小板介导的炎症和潜在机制中没有任何关于PLD1诱导的GPIB调节。本研究旨在探讨PLD1对血小板介导的内皮和白细胞募集和体外活化的相关性。

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来源
《Cellular Signalling》 |2017年第2017期|共11页
作者
Klier Meike; Gowert Nina Sarah; Jaeckel Sven; Reinhardt Christoph; Elvers Margitta;
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作者单位

Heinrich Heine Univ Med Ctr Dept Vasc &

Endovasc Surg Moorenstr 5 D-40225 Dusseldorf Germany;

Heinrich Heine Univ Med Ctr Dept Vasc &

Endovasc Surg Moorenstr 5 D-40225 Dusseldorf Germany;

German Ctr Cardiovasc Res DZHK Partner Site RheinMain Mainz Germany;

German Ctr Cardiovasc Res DZHK Partner Site RheinMain Mainz Germany;

Heinrich Heine Univ Med Ctr Dept Vasc &

Endovasc Surg Moorenstr 5 D-40225 Dusseldorf Germany;

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原文格式 PDF
正文语种 eng
中图分类细胞形态学;
关键词
Phospholipase D1; Platelets; Inflammation; Glycoprotein Ib; Leukocytes; Endothelial cells;

机译：磷脂酶D1;血小板;炎症;糖蛋白IB;白细胞;内皮细胞;

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1. Phospholipase D1 is a regulator of platelet-mediated inflammation [J] . Klier Meike, Gowert Nina Sarah, Jaeckel Sven, Cellular Signalling . 2017,第期

机译：磷脂酶D1是血小板介导的炎症的调节剂
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机译：Nod1 / 2双重缺陷小鼠的表型及其在全身性炎症和相关性肾脏疾病中的特征Nod1 / 2双重缺陷小鼠的表型与系统性炎症及相关性肾脏疾病中的Nod1 / 2表征炎症和相关性肾脏疾病中Nod1 / 2的表达和特征
3. Beta 1 integrin cross-linking inhibits CD16-induced phospholipase D and secretory phospholipase A2 activity and granule exocytosis in human NK cells: role of phospholipase D in CD16-triggered degranulation. [J] . Milella M, Gismondi A, Roncaioli P, The Journal of Immunology: Official Journal of the American Association of Immunologists . 1999,第4期

机译：Beta 1整联蛋白交联抑制人NK细胞中CD16诱导的磷脂酶D和分泌性磷脂酶A2活性以及颗粒胞吐作用：磷脂酶D在CD16触发的脱粒中的作用。
4. CD137 reverse signaling in sterile inflammation: CD137L in sterile tissue inflammation [C] . Kwon Byungsuk, Cho Hong Rae 2012 7th International Forum on Strategic Technology. . 2012

机译：无菌炎症中的CD137反向信号传递：无菌组织炎症中的CD137L
5. Studies of phospholipase D1 and phospholipase D2 expression in rat brain during development and aging and identification of a physiological role for phospholipase D2 in providing the precursor choline for acetylcholine synthesis. [D] . Zhao, Di. 2002

机译：研究磷脂酶D1和磷脂酶D2在大鼠大脑发育和衰老过程中的表达，并鉴定磷脂酶D2在提供乙酰胆碱合成前体胆碱中的生理作用。
6. Presenilin-1 uses phospholipase D1 as a negative regulator of β-amyloid formation [O] . Dongming Cai, William J. Netzer, Minghao Zhong, 2006

机译：Presenilin-1使用磷脂酶D1作为β淀粉样蛋白形成的负调节剂
7. Presenilin-1 uses phospholipase D1 as a negative regulator of β-amyloid formation [O] . Cai, Dongming, Netzer, William J., Zhong, Minghao, 2006

机译：Presenilin-1使用磷脂酶D1作为β淀粉样蛋白形成的负调节剂

Phospholipase D1 is a regulator of platelet-mediated inflammation

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