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Chemical Structures of Novel Maillard Reaction Products under Hyperglycemic Conditions

机译：高血糖条件下新型美丽反应产物的化学结构

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摘要

Two novel and two known compounds, 4-quinolylaldoxime and indole-3-aldehyde, were isolated from a reaction mixture consisting of D-glucose and L-tryptophan at physiological temperature and pH. The chemical structures of the two novel compounds were elucidated by spectroscopic analysis such as X-ray crystallography. One of the novel compound and the indole-3-aldehyde showed mutagenicity toward Salmonella typhimurium YG1024 with S9 mix. Furthermore, 4-quinolylaldoxime was detected from streptozotocin-induced diabetic rat plasma by LC-MS/MS analysis; however, the isolated compounds were not detected in rat diet extracts. To our knowledge, this is the first report in which 4-quinolylaldoxime was detected in rat plasma. These results suggest that amino-carbonyl reaction products may be formed in diabetic condition and induce genetic damage.
机译：两种新颖的和两种已知的化合物，4-喹啉肟和吲哚-3-醛从生理温度和pH中的D-葡萄糖和L-色氨酸组成的反应混合物中分离出来。 通过光谱分析（如X射线晶体学），阐明了两种新化合物的化学结构。 其中一种新型化合物和吲哚-3-醛显示出致沙门氏菌培氏硫脲YG1024的致突变性，S9混合。 此外，通过LC-MS / MS分析从链脲佐菌素诱导的糖尿病大鼠血浆中检测到4-喹啉基氧化肟; 然而，在大鼠饮食提取物中未检测到分离的化合物。 据我们所知，这是第一份报告，其中在大鼠血浆中检测到4-喹啉基肟。 这些结果表明氨基 - 羰基反应产物可以形成为糖尿病病症并诱导遗传损伤。

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