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首页> 外文期刊>Acta ophthalmologica Scandinavica >Quantifying the effect of intraocular pressure reduction on the occurrence of glaucoma
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Quantifying the effect of intraocular pressure reduction on the occurrence of glaucoma

机译：量化眼压降低对青光眼发生的影响

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摘要

Purpose: To estimate the effect of reducing intraocular pressure (IOP) on: (i) the incidence of primary open-angle glaucoma (POAG) in patients with ocular hypertension (OH), and (ii) the progression of glaucoma. Methods: A meta-analysis of relevant randomized controlled trials was conducted. A literature search was performed to identify trials with: a randomized comparison of IOP-lowering intervention versus placebo or no treatment; visual field loss or optic disc changes as outcome; and follow-up > 6 months. A pooled relative risk (RR) was calculated by a random effects model. Risk reduction of glaucoma conversion per mmHg of IOP reduction was quantified in a meta-regression model.Results: We identified nine OH and one POAG trials. A meta-analysis of OH trials gives a pooled RR of 0.61 [95% confidence interval (CI) 0.45-0.83]. A meta-regression shows a decrease of the RR of glaucoma conversion by 14% with each mmHg extra IOP reduction (P = 0.045). No meta-analysis of POAG trials was performed because only one study has been identified. Conclusion: There is sufficient evidence that OH therapy reduces the risk of conversion to glaucoma. This risk reduction increases with greater IOP reduction.
机译：目的：评估降低眼内压（IOP）的作用：（i）高眼压（OH）患者的原发性开角型青光眼（POAG）的发生率，以及（ii）青光眼的进展。方法：对相关随机对照试验进行荟萃分析。进行文献检索以鉴定以下试验：降低眼压的干预与安慰剂或不治疗的随机比较;视力减退或视盘改变作为结果;并随访> 6个月。通过随机效应模型计算合并的相对风险（RR）。在荟萃回归模型中，每降低IOP的mmHg减少青光眼转化的风险。结果：我们确定了9项OH和1项POAG试验。 OH试验的荟萃分析得出的合并RR为0.61 [95％置信区间（CI）0.45-0.83]。荟萃回归显示，每增加mmHg眼压，青光眼转化率RR降低14％（P = 0.045）。由于仅发现一项研究，因此未进行POAG试验的荟萃分析。结论：有足够的证据表明，OH治疗可降低转化为青光眼的风险。随着降低IOP的增加，这种风险降低也会增加。

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