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首页> 外文期刊>Acta ophthalmologica Scandinavica >Diagnostic accuracy of Heidelberg Retina Tomograph III classifications in a Turkish primary open-angle glaucoma population
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Diagnostic accuracy of Heidelberg Retina Tomograph III classifications in a Turkish primary open-angle glaucoma population

机译：海德堡视网膜断层扫描仪III分类对土耳其原发性开角型青光眼人群的诊断准确性

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Purpose: This study aimed to evaluate the diagnostic accuracy of Moorfields regression analysis (MRA) and the glaucoma probability score (GPS) in primary open-angle glaucoma (POAG) and to measure the level of agreement between the two algorithms in classifying eyes as normal or abnormal in a Turkish population. Methods: We prospectively selected 184 healthy subjects and 158 subjects with POAG, who underwent an ophthalmological examination, visual field analysis and imaging with the Heidelberg Retina Tomograph II, using HRT III software, Version 3.0. The diagnostic accuracies of the two classifications were measured when the borderline was taken as either normal (highest specificity criteria) or abnormal (highest sensitivity criteria). The agreement between them was calculated using the unweighted kappa (k) coefficient. Results: Optic nerve head topographic parameters showed statistically significant differences between the control and POAG groups (p < 0.001). The parameters with the highest area under the receiver operating characteristic curves were global GPS (0.86), cup : disc area (0.85), rim : disc area (0.85) and vertical cup : -disc (0.85). According to the highest specificity criteria, MRA had a sensitivity of 67.7% and a specificity of 95.1%, whereas the GPS had a sensitivity of 70.9% and a specificity of 88.0%. According to the highest sensitivity criteria, MRA had a sensitivity of 81.0% and a specificity of 75.0%, whereas the GPS had a sensitivity of 89.2% and a specificity of 57.6%. A moderate agreement of 68% (233 eyes) with a k coefficient of 0.51 was found between MRA and the GPS. Conclusions: The GPS automated classification showed similar sensitivity to MRA, but considerably lower specificity, when applied in a Turkish population.
机译：目的：本研究旨在评估Moorfields回归分析（MRA）和青光眼几率评分（GPS）对原发性开角型青光眼（POAG）的诊断准确性，并衡量将这两种算法归类为正常眼的两种算法之间的一致性水平或在土耳其人口中异常。方法：我们前瞻性选择了184名健康受试者和158名POAG受试者，他们使用HRT III软件3.0版通过Heidelberg Retina Tomograph II进行了眼科检查，视野分析和成像。当将界线视为正常（最高特异性标准）或异常（最高灵敏度标准）时，对两种分类的诊断准确性进行了测量。使用未加权的kappa（k）系数计算它们之间的一致性。结果：视神经头的地形参数显示，对照组和POAG组之间的差异具有统计学意义（p <0.001）。接收器工作特性曲线下面积最大的参数是全局GPS（0.86），杯形：圆盘面积（0.85），边缘：圆盘面积（0.85）和垂直杯形-碟（0.85）。根据最高的特异性标准，MRA的敏感性为67.7％，特异性为95.1％，而GPS的敏感性为70.9％，特异性为88.0％。根据最高灵敏度标准，MRA的灵敏度为81.0％，特异性为75.0％，而GPS的灵敏度为89.2％，特异性为57.6％。在MRA和GPS之间发现有68％（233眼）的中度一致性，k系数为0.51。结论：GPS自动分类对MRA具有相似的敏感性，但在土耳其人群中应用时特异性较低。

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