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Skin aging: the dermal perspective

机译：皮肤老化：真皮的角度

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The world population of adults aged 60 years or more is increasing globally, and this development can impact skin disease morbidity and mortality, as well as being reflected in the health care system organization. There is substantial evidence that the burden from a remarkable number of skin nonmalignant and malignant conditions is greater in the elderly. Dermatologic research and clinical education in dermatology should focus on both challenges and opportunities created by aging. Skin aging due to intrinsic and extrinsic factors can alter significantly epidermal and dermal structure and functions. Dermal aging can be linked to a great number of complications in routine dermatologic conditions, with slow healing as an example of a severe complication in the elderly. This may be attributed to aged dermal fibroblasts modifying the tissue microenvironment via a shift in their soluble factors and extracellular matrix repertoire. This senescence associated secretory phenotype can explain the particular proclivity of aged skin to develop malignancies. (C) 2019 Published by Elsevier Inc.
机译：世界上60岁或更长时间的世界人口在全球范围内增加，这种发展可以影响皮肤病的发病率和死亡率，并反映在医疗保健系统组织中。有很大的证据表明，老年人的显着数量的皮肤非开始和恶性条件的负担更大。皮肤科的皮肤病学研究和临床教育应侧重于老龄化创造的挑战和机会。由于内在和外在因子导致的皮肤衰老可以改变显着的表皮和皮肤结构和功能。皮肤老化可以与常规皮肤病病症中的大量并发症相关联，愈合缓慢，作为老年人严重并发症的一个例子。这可能归因于老化的皮肤成纤维细胞通过可溶性因子和细胞外基质曲目中的偏移改变组织微环境。这种衰老相关的分泌表型可以解释老年皮肤的特定倾向，以发展恶性肿瘤。 （c）2019由elsevier公司出版

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