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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Corrigendum to 'Immunopathology in influenza virus infection: Uncoupling the friend from foe' [Clin. Immunol. 144 (2012) 57-69]
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Corrigendum to 'Immunopathology in influenza virus infection: Uncoupling the friend from foe' [Clin. Immunol. 144 (2012) 57-69]

机译：“流感病毒感染免疫病理学的勘探：从敌人解耦的朋友”[临床。 免疫素。 144（2012）57-69]

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The prevalence and incidence of asthma have increased among obese children and adults, particularly among women. Obesity seems to be a predisposing factor for the development of asthma, but the underlying mechanisms of its influence are still uncertain. Various hypotheses have been proposed to explain the link between obesity and asthma such as a common genetic predisposition, developmental changes, altered lung mechanics, the presence of a systemic inflammatory process, and an increased prevalence of associated comorbid conditions. Over-diagnosis of asthma does not seem to be more frequent in obese compared to non-obese subjects, but the added effects of obesity on respiratory symptoms can affect asthma control assessment. Obesity can make asthma more difficult to control and is associated with a reduced beneficial effect of asthma medications. This could be due to a change in asthma phenotype, particularly evidenced as a less eosinophilic type of airway inflammation combined to the added effects of changes in lung mechanics. Weight loss is associated with a universal improvement of asthma and should be part of asthma management in the obese patient. Additional research should be conducted to better determine how obesity influences the development and clinical expression of asthma, establish the optimal management of asthma in this population and determine how obesity affects long-term asthma outcomes in these patients.
机译：肥胖儿童和成人患者的患病率和发病率增加，特别是女性。肥胖似乎是哮喘发展的概述因素，但其影响的潜在机制仍然不确定。已经提出了各种假设来解释肥胖症和哮喘之间的联系，例如常见的遗传易感性，发育变化，改变肺部力学，全身炎症过程的存在，以及相关的合并症的患病率增加。与非肥胖的受试者相比，肥胖的过度诊断似乎在肥胖中似乎并不常见，但肥胖的增加对呼吸系统症状的影响可能会影响哮喘控制评估。肥胖可以使哮喘更难以控制，并且与哮喘药物的有益效果降低有关。这可能是由于哮喘表型的变化，特别证明是一种较少的嗜酸性类型的气道炎症，组合肺部力学变化的额外影响。减肥与哮喘的普遍改善有关，应该是肥胖患者哮喘管理的一部分。应进行额外的研究以更好地确定肥胖如何影响哮喘的开发和临床表达，在该人群中建立哮喘的最佳管理，并确定肥胖如何影响这些患者的长期哮喘结果。

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