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首页> 外文期刊>Acta Obstetricia et Gynecologica Scandinavica: Official Publication of the Nordisk Forening for Obstetrik och Gynekologi >Use of analgesic drugs and risk of ovarian cancer: Results from a Danish case-control study
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Use of analgesic drugs and risk of ovarian cancer: Results from a Danish case-control study

机译：镇痛药的使用和卵巢癌的风险：丹麦病例对照研究的结果

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Objective. The role of analgesic drug use in development of ovarian cancer is not fully understood. We examined the association between analgesic use and risk of ovarian cancer. In addition, we examined whether the association differed according to histological types. Design. Population-based case-control study. Setting. Denmark in the period 1995-1999. Population. We included 756 women with epithelial ovarian cancer and 1564 randomly selected control women aged 35-79 years. Methods. Information on analgesic drug use was collected from personal interviews. Analgesic drugs were divided into the following categories: any analgesics; aspirin; non-aspirin non-steroidal anti-inflammatory drugs; paracetamol; and other analgesic drugs. The association between analgesic drug use and ovarian cancer risk was analysed using multiple logistic regression models. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated. Main outcome measures. Epithelial ovarian cancer. Results. Women with a regular use of any analgesics (OR = 0.79; 95% CI 0.62 - 1.01) or aspirin (OR = 0.68; 95% CI 0.46 - 1.02) had a decreased risk of ovarian cancer, although not statistically significant. Regular use of non-aspirin non-steroidal anti-inflammatory drugs, paracetamol or other analgesics did not decrease ovarian cancer risk. Use of any analgesics (OR = 0.72; 95% CI 0.53-0.98) or aspirin (OR = 0.60; 95% CI 0.36-1.00) resulted in a statistically significant decreased risk of serous ovarian cancer but not mucinous or other ovarian tumors. Conclusion. In accordance with most previous studies, our results indicate a possible inverse association between analgesic use, particularly aspirin, and ovarian cancer risk.
机译：目的。止痛药在卵巢癌发生中的作用尚不完全清楚。我们研究了止痛药与卵巢癌风险之间的关联。此外，我们检查了关联是否根据组织学类型而有所不同。设计。基于人群的病例对照研究。设置。丹麦在1995-1999年期间。人口。我们纳入了756名患有上皮性卵巢癌的女性和1564名年龄在35-79岁之间的随机对照女性。方法。通过个人访谈收集了有关止痛药使用的信息。镇痛药分为以下几类：任何止痛药;阿司匹林;非阿司匹林非甾体抗炎药;扑热息痛;和其他止痛药。使用多种逻辑回归模型分析了止痛药使用与卵巢癌风险之间的关联。估计赔率（OR）和95％置信区间（CI）。主要观察指标。上皮性卵巢癌。结果。定期使用任何止痛药（OR = 0.79; 95％CI 0.62-1.01）或阿司匹林（OR = 0.68; 95％CI 0.46-1.02）的妇女患卵巢癌的风险降低，尽管无统计学意义。定期使用非阿司匹林非甾体抗炎药，扑热息痛或其他镇痛药不会降低卵巢癌的风险。使用任何镇痛药（OR = 0.72; 95％CI 0.53-0.98）或阿司匹林（OR = 0.60; 95％CI 0.36-1.00）导致浆液性卵巢癌的风险统计学上显着降低，但粘液性或其他卵巢肿瘤则没有统计学意义。结论。根据大多数先前的研究，我们的结果表明止痛药（尤其是阿司匹林）与卵巢癌风险之间可能存在负相关关系。

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