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首页> 外文期刊>Critical reviews in immunology >DNA Vaccines – A Modern Gimmick or a Boon to Vaccinology?
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DNA Vaccines – A Modern Gimmick or a Boon to Vaccinology?

机译：DNA疫苗 - 现代噱头或疫苗学的福音？

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The reports in 1993 that naked DNA encoding viral genes conferred protective immunity came as a surprise to most vaccinologists. This review analyses the expanding number of examples where plasmid DNA induces immune responses. Issues such as the type of immunity induced, mechanisms of immune protection, and how DNA vaccines compare with other approaches are emphasized. Additional issues discussed include the likely means by which DNA vaccines induce CTL, how the potency and type of immunity induced can be modified, and whether DNA vaccines represent a practical means of manipulating unwanted immune response occurring during immunoinflammatory diseases. It seems doubtful if DNA vaccines will replace currently effective vaccines, but they may prove useful for prophylactic use against some agents that at present lack an effective vaccine. DNA vaccines promise to be valuable to manipulate the immune response in situations where responses to agents are inappropriate or ineffective.
机译：1993年的报道中，编码病毒基因的裸体DNA赋予保护性免疫力是对大多数疫苗学家的惊喜。 该综述分析了质粒DNA诱导免疫应答的扩大数量。 强调，诸如免疫诱导，免疫保护机制的问题等问题，以及DNA疫苗与其他方法进行比较。 所讨论的其他问题包括DNA疫苗诱导CTL的可能意味着可以修饰诱导的免疫感应性和类型的效力，以及DNA疫苗是否代表在免疫炎症疾病期间在免疫炎症疾病中进行不需要的免疫应答的实用手段。 如果DNA疫苗替代目前有效的疫苗，它们似乎是值得怀疑的，但它们可能对预防性用于某些目前缺乏有效疫苗的药剂来证明。 DNA疫苗承诺为在对药剂的反应不恰当或无效的情况下操纵免疫应答的价值。

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