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Immunotherapy for the Treatment of Breast Cancer

机译:免疫疗法治疗乳腺癌

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摘要

Decades of research are now leading to therapeutics that target the molecular mechanisms of the cancer-specific immune response. These therapeutics include tumor antigen vaccines, dendritic cell activators, adjuvants that activate innate immunity, adoptive cellular therapy, and checkpoint blockade. The advances in targeted immunotherapy have led to clinical advances in the treatment of solid tumors such as melanoma, prostate cancer, lung cancer, and hematologic malignancies. Preclinical and translational studies suggest that patients with breast cancer may also benefit from augmenting effective immune responses. These results have led to early-phase clinical trials of tumor antigen vaccines, adjuvants, and combinations of checkpoint inhibitor blockade to boost breast cancer-specific immunity in patients. This review focuses on the current and emerging development of cancer immunotherapy for breast cancer.
机译:现在研究的几十年的研究旨在瞄准癌症特异性免疫反应的分子机制。 这些治疗剂包括肿瘤抗原疫苗,树突式细胞活化剂,激活先天免疫,养护细胞疗法和检查站封闭的佐剂。 靶向免疫疗法的进展导致了治疗同性恋瘤,前列腺癌,肺癌和血液学恶性肿瘤等固体肿瘤的临床进步。 临床前和翻译研究表明,乳腺癌的患者也可能受益于增强有效的免疫反应。 这些结果导致了肿瘤抗原疫苗,佐剂的早期临床试验,以及检查点抑制剂阻滞的组合,以提高患者的乳腺癌特异性免疫。 该综述侧重于乳腺癌癌症免疫疗法的当前和新兴发展。

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