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首页> 外文期刊>Current opinion in gastroenterology >Eosinophilic esophagitis: Diagnostic tests and criteria
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Eosinophilic esophagitis: Diagnostic tests and criteria

机译：嗜酸性食管炎：诊断测试和标准

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摘要

Purpose of review: To present the clinical, endoscopic, and histologic features of eosinophilic esophagitis (EoE), review the current diagnostic guidelines for EoE, and present an approach for diagnosis of EoE. It will also highlight selected techniques that are under development that may be useful in the future for diagnosis of EoE. Recent findings: Recently updated guidelines emphasize that EoE is a clinicopathologic condition. Specifically, three criteria must be met to diagnose EoE: clinical symptoms of esophageal dysfunction; an esophageal biopsy with a maximum eosinophil count of at least 15 eosinophils per high-power microscopy field, with few exceptions; and exclusion of other possible causes of esophageal eosinophilia, including proton-pump inhibitor responsive esophageal eosinophilia (PPI-REE). A PPI trial is typically required both to assess for PPI-REE and to evaluate for the presence of concomitant gastroesophageal reflux disease. Summary: EoE is a chronic, immune-mediated disorder. Because no single symptom, endoscopic finding, or histopathologic feature is pathognomonic, diagnosis can be challenging. In the future, symptom scores, tissue or serum biomarkers, and genetic testing may play a role in diagnosis, but these methods have yet to be validated and are not yet recommended for routine clinical use.
机译：审查目的：介绍嗜酸性食管炎（EOE）的临床，内窥镜和组织学特征，审查目前的EOE诊断指南，并提出了eoe的诊断方法。它还将突出显示正在开发的所选技术，以便在将来可用以进行诊断EOE。最近的调查结果：最近更新的指导方针强调EOE是临床病理病症。具体而言，必须满足三个标准诊断EOE：食管功能障碍的临床症状;食管活检，每个大功率显微镜场至少15个嗜酸性粒细胞的最大嗜酸性粒细胞计数，少数例外;排除食管嗜酸性粒细胞的其他可能原因，包括质子泵抑制剂响应食管嗜酸性粒细胞（PPI-REE）。通常需要评估PPI-REE并评估伴随的胃食管反流疾病的存在。摘要：EOE是一种慢性，免疫介导的疾病。因为没有单一的症状，内窥镜发现或组织病理学特征是公开的，所以诊断可能具有挑战性。在未来，症状评分，组织或血清生物标志物和遗传检测可能在诊断中发挥作用，但这些方法尚未得到验证，尚未推荐用于常规临床使用。

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