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HDL functionality

机译：HDL功能

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Purpose of Review: HDL cholesterol concentration is inversely correlated with cardiovascular disease and has a wide range of functions involved in many systems. The purpose of this review is to summarize HDL functionality, its relevance to atherosclerosis and factors affecting HDL functions. Recent Findings: The contribution of HDL to reverse cholesterol transport may not be as great as first envisaged. However, it still plays an important role in cholesterol efflux from peripheral tissues. The capacity of HDL to promote cellular cholesterol efflux in an ex-vivo model has been reported to correlate more closely with carotid intima-media thickness than HDL cholesterol concentration. Recently, a variety of other functions of HDL have been described including antimicrobial, antioxidant, antiglycation, anti-inflammatory, nitric oxide-inducing, antithrombotic and antiatherogenic activity and immune modulation as well as a potential role in glucose homeostasis, diabetes pathophysiology and complications. Summary: HDL has a wide range of functions some of which are independent of its cholesterol content. Its cargo of apolipoproteins, various proteins and phospholipids contributes most to its various functions. These functions are affected by a number of genetic, physiological and pathological factors.
机译：审查目的：HDL胆固醇浓度与心血管疾病与心血管疾病相似，并且具有许多系统涉及的各种功能。本综述的目的是总结HDL功能，其与影响HDL功能的动脉粥样硬化和因素的相关性。最近的发现：HDL对逆转胆固醇运输的贡献可能不如第一次设想那么大。然而，它仍然在外周组织中的胆固醇流出中起重要作用。据报道，HDL在前体内模型中促进细胞胆固醇流出的能力与颈动脉内膜厚度比HDL胆固醇浓度更紧密地相关。最近，已经描述了多种其他HDL功能，包括抗微生物，抗氧化剂，抗饱和，抗炎，一氧化氮诱导，抗血栓和抗血管生成活性以及免疫调节以及在葡萄糖稳态，糖尿病病理生理学和并发症中的潜在作用。发明内容：HDL具有广泛的功能，其中一些功能与其胆固醇内容无关。它的载脂蛋白的货物，各种蛋白质和磷脂有助于其各种功能。这些功能受许多遗传，生理和病理因素的影响。

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