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Utility of Apparent Diffusion Coefficient Ratios in Distinguishing Common Pediatric Cerebellar Tumors

机译：鉴别常见的小脑肿瘤表观扩散系数比的效用

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摘要

Rationale and Objectives: The aim of this study was to identify clinically useful tumor/normal brain apparent diffusion coefficient (ADC) ratios for distinguishing common pediatric cerebellar tumors. Materials and Methods: Review of medical records revealed 79 patients with cerebellar tumors who underwent preoperative magnetic resonance imaging, including diffusion-weighted imaging sequences, and surgery. There were 31 pilocytic astrocytomas, 27 medulloblastomas, 14 ependymomas, and seven atypical teratoid/rhabdoid tumors. ADC values were measured by placing regions of interest on the solid tumor and normal brain parenchyma by two reviewers. Tumor/normal brain ADC ratios were calculated. Results: Mean ADC values of the pilocytic astrocytomas were greater than those of ependymomas, whose mean ADC values were greater than those of medulloblastomas and atypical teratoid/rhabdoid tumors. Using a tumor/normal brain ADC ratio threshold of 1.70 to distinguish pilocytic astrocytomas from ependymomas, sensitivity of 92% and specificity of 79% were achieved. A tumor/normal brain ADC ratio threshold of 1.20 enabled the sorting of ependymomas from medulloblastomas with sensitivity of 93% and specificity of 88%. Conclusions: Tumor/normal brain ADC ratios allow the distinguishing of common pediatric cerebellar tumors.
机译：理由和目标：本研究的目的是鉴定临床上有用的肿瘤/正常脑表观扩散系数（ADC）比例，以区分常见的儿科小脑肿瘤。材料和方法：审查医疗记录揭示了79例小脑肿瘤的术前磁共振成像，包括扩散加权成像序列和手术。有31个硫霉菌星形细胞瘤，27例Medulloblastomas，14个Enencyomas和七种非典型Teratoid / Rhabdoid肿瘤。通过将患者的实体肿瘤和正常脑干细胞放置有利息区域来测量ADC值。计算肿瘤/正常脑ADC比率。结果：平均星形细胞瘤的平均值大于Enencyymas的adc值，其平均ADC值大于Medulloblastomas和非典型陶瓷/ rhabdoid肿瘤。使用肿瘤/正常脑ADC比率阈值1.70以区分鳞片状星形细胞瘤从Enencyymas区分，达到92％的敏感性和79％的特异性。 1.20的肿瘤/正常脑ADC比率阈值使Smulloblastomas排序具有93％的敏感性，特异性为88％。结论：肿瘤/正常脑ADC比率允许区分常见的儿科小脑肿瘤。

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  • 来源
    《Academic radiology》 |2012年第7期|共7页
  • 作者

    GimiB.; CederbergK.; DerinkuyuB.; GarganL.; KoralK.M.; BowersD.C.; KoralK.;

  • 作者单位

    Department of Radiology Dartmouth Medical School Hanover NH United States;

    Department of Radiology University of Texas Southwestern Medical Center and Children's Medical;

    Department of Radiology Ankara University Medical School Ankara Turkey;

    Department of Neuro-Oncology Children's Medical Center Dallas Tx United States;

    Department of Radiology VA North Texas Healthcare System Dallas TX United States;

    Department of Pediatrics University of Texas Southwestern Medical Center and Children's Medical;

    Department of Radiology University of Texas Southwestern Medical Center and Children's Medical;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 放射医学;
  • 关键词

    Apparent diffusion coefficient value; Cerebellar tumor; Children; Diffusion weighted imaging;

    机译：表观扩散系数值;小脑肿瘤;儿童;扩散加权成像;

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