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Breast-specific gamma imaging in the detection of atypical ductal hyperplasia and lobular Neoplasia

机译：乳腺特异性γ成像检测非典型导管增生和小叶瘤

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摘要

Rationale and Objectives: Atypical lesions such as atypical ductal hyperplasia (ADH) and lobular neoplasia are nonmalignant lesions that are associated with significant increased risk of developing breast cancer. Atypical lesions have been reported to present with focal increased radiotracer uptake on breast-specific gamma imaging (BSGI) examination, a novel physiologic tool for the detection of breast cancer. To date the sensitivity of BSGI in the detection of atypical lesions has not been reported. The purpose of this study is to determine the sensitivity of BSGI in detecting ADH and lobular neoplasia. Materials and Methods: A total of 1316 patients who received a BSGI exam between January 2006 and July 2009 were retrospectively reviewed. All patients who underwent minimally invasive biopsy and subsequent surgical excision where the highest pathology was solely ADH or lobular neoplasia (reported as ALH, lobular carcinoma in situ or lobular neoplasia), according to the pathology database were included (n = 15). The sensitivity was determined as the percentage of positive BSGI exams out of all patients diagnosed with ADH or lobular neoplasia who received a BSGI. Results: Patient ages ranged from 39 to 67 (mean, 52). Eight of 15 patients had ADH, 6/15 lobular neoplasia, and 1/15 ADH and lobular neoplasia in one lesion. Fifteen of the 15 (100%) patients with surgically confirmed ADH or lobular neoplasia had a positive BSGI, with focally increased radiotracer uptake at the site of the verified high-risk lesion. Conclusion: BSGI has a high sensitivity for the detection of atypical, high-risk breast lesions. A diagnosis of an atypical lesion is concordant with focal increased radiotracer uptake with BSGI and can identify women at increased risk for breast cancer.
机译：理由和目标：非典型导管增生（ADH）和小叶肿瘤等非型病变是非恶性病变，其具有显着增加乳腺癌的风险。据报道，非典型病变呈现出局灶性增加的乳腺癌γ成像（BSGI）检查，一种用于检测乳腺癌的新型生理工具。迄今为止，尚未报告BSGI在检测到非典型病变中的敏感性。本研究的目的是确定BSGI在检测ADH和小叶瘤的敏感性。材料和方法：回顾性审查2006年1月至2009年1月至2009年7月期间收到BSGI考试的1316名患者。所有患者接受了最微创活检和随后的手术切除，其中最高病理学仅仅是ADH或左侧肿瘤（原位或左侧或小叶瘤的alh，雄性癌）（n = 15）。敏感性被确定为患有接受BSGI的ADH或小叶肿瘤的所有患者的阳性BSGI考试的百分比。结果：患者年龄从39到67（平均值，52）。 15名患者中有八个患者患有ADH，6/15小叶肿瘤，1/15 ADH和一个病变中的肾小瓣瘤。 15（100％）患有手术证实的ADH或小叶肿瘤患者的十五个患者具有阳性BSGI，源于验证的高风险病变部位的放射性反射液吸收。结论：BSGI对非典型高风险乳房病变的检测具有很高的灵敏度。诊断非典型病变的诊断是局灶性增加的反毒蛋白摄取与BSGI的一致性，并且可以鉴定乳腺癌风险增加的妇女。

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  • 来源
    《Academic radiology》 |2012年第6期|共6页
  • 作者

    LingC.M.; CoffeyC.M.; RapelyeaJ.A.; TorrenteJ.; TealC.B.; McSwainA.P.; BremR.F.;

  • 作者单位

    Breast Imaging and Interventional Center Department of Radiology The George Washington University;

    Breast Imaging and Interventional Center Department of Radiology The George Washington University;

    Breast Imaging and Interventional Center Department of Radiology The George Washington University;

    Breast Imaging and Interventional Center Department of Radiology The George Washington University;

    Department of Surgery The George Washington University Medical Faculty Associates Washington DC;

    Department of Surgery The George Washington University Medical Faculty Associates Washington DC;

    Department of Surgery The George Washington University Medical Faculty Associates Washington DC;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 放射医学;
  • 关键词

    Atypical ductal hyperplasia; Breast-specific gamma imaging; High-risk breast lesions; Lobular carcinoma in situ; Lobular neoplasia;

    机译：非典型导管增生;乳房特异性γ成像;高风险的乳房病变;原位小叶癌;小叶肿瘤;

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