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首页> 外文期刊>Academic radiology >Clinical Significance of Combined Assessment of the Maximum Standardized Uptake Value of F-18 FDG PET with Nodal Size in the Diagnosis of Cervical Lymph Node Metastasis of Oral Squamous Cell Carcinoma
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Clinical Significance of Combined Assessment of the Maximum Standardized Uptake Value of F-18 FDG PET with Nodal Size in the Diagnosis of Cervical Lymph Node Metastasis of Oral Squamous Cell Carcinoma

机译：结合F-18 FDG PET的最大标准化摄取价值的临床意义在颈淋巴结宫颈淋巴结转移中的诊断中

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摘要

Rationale and Objectives: This study aimed to elucidate the diagnostic accuracy of F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) for nodal involvement in oral squamous cell carcinoma (OSCC), and to reveal clinically useful factors to distinguish between true-positive (TP) and false-positive (FP) nodes. Materials and Methods: Thirty-eight patients with primary OSCC who underwent neck dissection were assessed. The diagnostic accuracy of F-18 FDG PET/CT was evaluated, and then compared with that of CT/ultrasonography (US). Furthermore, the association of the maximum standardized uptake value (SUVmax) and nodal size with the histopathologic findings was examined. Results: Sensitivity and specificity using F-18 FDG PET/CT were 77.1% and 97.3%, and those using CT/US were 72.9% and 98.9%, respectively. The SUVmax of TP nodes was significantly higher than that of FP nodes. Nodes with SUVmax >4.5 were pathologically confirmed as metastasis. Nodes with SUVmax ≤4.5 were further discriminated between TP and FP nodes by using the long axis diameters or the ratios of long to short axis diameter as clinical parameters. Positive correlation between the SUVmax and the short-axis diameter was found in TP nodes. The AUC obtained from the ROC curves of the SUVmax alone (AUC, 0.804) was improved by combination with the long-axis diameter (AUC, 0.867) or the short-axis diameter (AUC, 0.846), although no significant difference was found. Conclusions: These results indicated that F-18 FDG PET/CT was potentially useful in diagnosing preoperative nodal state. Furthermore, combined assessment of SUVmax with nodal size could be significant in the identification of metastatic lymph nodes in OSCC patients.
机译：理由和目标：本研究旨在阐明F-18氟脱氧葡萄糖（FDG）正电子发射断层扫描（PET）/计算机断层扫描（CT）的诊断准确性，用于核心鳞状细胞癌（OSCC）的节点参与，并揭示临床有用因素区分真正正（TP）和假正（FP）节点。材料和方法：评估颈部剖检的初级OSCC的38名患者。评估F-18 FDG PET / CT的诊断准确性，然后与CT /超声检查（US）进行比较。此外，检查了最大标准化摄取值（SUVMAX）和Nodal大小与组织病理学发现的关联。结果：使用F-18 FDG PET / CT的敏感性和特异性为77.1％和97.3％，使用CT / US的敏感性分别为72.9％和98.9％。 TP节点的SUVMAX显着高于FP节点。具有Suvmax> 4.5的节点在病理学上证实转移。通过使用长轴直径或长到短轴直径的长轴直径作为临床参数，通过使用长轴直径或长达短轴直径的比率在TP和FP节点之间进一步区分具有SUVMAX≤4.5的节点。在TP节点中发现了Suvmax和短轴直径之间的正相关。通过与长轴直径（AUC，0.867）或短轴直径（AUC，0.846）的组合而改善了单独的SUVMAX的ROC曲线（AUC，0.804）获得的AUC，尽管未发现显着差异。结论：这些结果表明F-18 FDG PET / CT可能可用于诊断术前节点状态。此外，Suvmax的组合评估在OSCC患者的鉴定中可能是显着的。

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  • 来源
    《Academic radiology》 |2012年第6期|共10页
  • 作者

    MatsubaraR.; KawanoS.; ChikuiT.; KiyosueT.; GotoY.; HiranoM.; JinnoT.; NagataT.; OobuK.; AbeK.; NakamuraS.;

  • 作者单位

    Section of Oral and Maxillofacial Oncology Division of Maxillofacial Diagnostic and Surgical;

    Section of Oral and Maxillofacial Oncology Division of Maxillofacial Diagnostic and Surgical;

    Section of Oral and Maxillofacial Radiology Division of Maxillofacial Diagnostic and Surgical;

    Section of Oral and Maxillofacial Oncology Division of Maxillofacial Diagnostic and Surgical;

    Section of Oral and Maxillofacial Oncology Division of Maxillofacial Diagnostic and Surgical;

    Section of Oral and Maxillofacial Oncology Division of Maxillofacial Diagnostic and Surgical;

    Section of Oral and Maxillofacial Oncology Division of Maxillofacial Diagnostic and Surgical;

    Department of Oral and Maxillofacial Surgery School of Medicine Hamamatsu University Higashi-ku;

    Section of Oral and Maxillofacial Oncology Division of Maxillofacial Diagnostic and Surgical;

    Department of Clinical Radiology Graduate School of Medical Sciences Kyushu University Higashi;

    Section of Oral and Maxillofacial Oncology Division of Maxillofacial Diagnostic and Surgical;

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  • 正文语种 eng
  • 中图分类 放射医学;
  • 关键词

    Cervical lymph node metastasis; Diagnosis; F-18 FDG-PET; Maximum standardized uptake value (SUVmax); Nodal size; Oral squamous cell carcinoma (OSCC);

    机译：颈淋巴结转移;诊断;F-18 FDG-PET;最大标准化摄取值（SUVMAX）;节点鳞状细胞癌（OSCC）;

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