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Automated Diffusion Tensor Tractography. Implementation and Comparison to User-driven Tractography

机译：自动扩散张量牵引牵引。 用户驱动牵引图的实施和比较

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摘要

Rationale and Objectives: Diffusion tensor tractography offers a unique perspective of white matter anatomy, but proper delineation of white matter tracts of interest generally requires the active involvement of an expert neuroanatomist. The investigators describe the implementation of an automated tractographic method requiring no user input and compare its results to those from user-driven tractography. Materials and Methods: Fourteen healthy volunteers underwent diffusion tensor imaging at 3 T. Images were registered to a standard template, and predefined seed regions containing tract termini were transformed into subject space for use in unsupervised probabilistic tractography. The output was compared to the results of user-driven tractography performed on the same subjects. Results: After the selection of suitable smoothing kernels and thresholds, the results of automated tractography closely approximated those of user-driven tractography. The main bodies of the cingulum, inferior fronto-occipital fasciculus, and inferior longitudinal fasciculus were depicted equally well by both methods. Discrepancies mainly arose at the periphery of these tracts, where anatomic uncertainty tends to be greatest. Conclusions: Automated tractography can be used to depict white matter anatomy without need for user intervention, particularly if the main body of the tract is of greatest interest.
机译：理由和目标：扩散张量牵伸术提供了白色物质解剖学的独特视角，但适当描绘了白质的感兴趣的白物暗影通常需要专家神经反应主义者的主动参与。调查人员描述了不需要用户输入的自动释放方法的实现，并将其结果与来自用户驱动的牵引图的结果进行比较。材料和方法：14个健康的志愿者在3T中接受了扩散张量成像。将图像注册到标准模板，并且将含有道末端的预定种子区域转化为对象空间以用于无监督的概率牵引器。将输出与在同一受试者上执行的用户驱动牵引的结果进行比较。结果：选择合适的平滑核和阈值后，自动牵引的结果紧密地近似于用户驱动的牵引图。通过两种方法同样地描绘了Cingulum，劣质前枕腔和较差的纵向束的主体。差异主要是在这些尸体的周边出现，其中解剖不确定性往往是最大的。结论：自动化牵引装置可用于描绘白质解剖，而无需使用用户干预，特别是如果道具的主体具有最大的兴趣。

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  • 来源
    《Academic radiology》 |2012年第5期|共8页
  • 作者

    NuciforaP.G.P.; WuX.; MelhemE.R.; GurR.E.; GurR.C.; VermaR.;

  • 作者单位

    Division of Neuroradiology University of Pennsylvania One Silverstein 3400 Spruce Street;

    Informatics Global Therapeutic Area for Immunology Johnson and Johnson Pharmaceuticals Research;

    Division of Neuroradiology University of Pennsylvania One Silverstein 3400 Spruce Street;

    Department of Psychiatry University of Pennsylvania One Silverstein 3400 Spruce Street;

    Department of Psychiatry University of Pennsylvania One Silverstein 3400 Spruce Street;

    Section of Biomedical Image Analysis University of Pennsylvania One Silverstein 3400 Spruce;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 放射医学;
  • 关键词

    Automation; Diffusion; Tractography;

    机译：自动化;扩散;牵引图;

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