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Registration-based metrics of lung function to describe copd: The ultimate question of life, the universe, and everything

机译：基于注册的肺功能指标描述COPD：终极问题，宇宙和一切

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摘要

We have a very complex organ (the lung), and on it is super imposed a very complicated disease, chronic obstructive pulmonary disease (COPD). How can we devise a simple value that gives us greater insight into this heterogeneous disease in this complex organ? How can we better assess COPD in patients? More important, how can we better determine the extent that ever-worsening COPD has on the lives of our patients? The pulmonary component of COPD is characterized by airflow limitation that is not fully reversible. The airflow limitation is usually progressive and associated with an abnormal inflammatory response of the lungs to noxious particles or gases (1), the most common of which is cigarette smoke. COPD is classically assessed by pulmonary function testing. Spirometry is a pulmonary function test (PFT) to determine the diagnosis and evaluate the severity of the disease. The ratio of the post-bronchodilator forced expiratory volume in 1 second divided by the forced vital capacity (FEV_1/FVC) <0.70 is the classic cut-off for a diagnosis of COPD (1). As the FEV_1/FVC ratio decreases, the severity of the disease increases. The generally accepted categorization of COPD severity classifies patients into four stages according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) classification (1). Can we devise a better way to assess the disease based on the directly viewed changes in the lungs in vivo?
机译：我们有一个非常复杂的器官（肺部），并且在它上超级施加了一个非常复杂的疾病，慢性阻塞性肺病（COPD）。我们如何设计一个简单的价值，使我们更加了解该复杂器官的这种异质疾病？我们如何更好地评估患者的COPD？更重要的是，我们如何更好地确定患者生命中令人厌恶的COPD的程度？ COPD的肺部分量的特征在于气流限制，不完全可逆。气流限制通常是渐进性的，并且与肺的异常炎症反应与有害颗粒或气体（1），最常见的是香烟烟雾。 COPD通过肺功能测试经典评估。 Spirometry是一种肺功能试验（PFT），用于确定诊断和评估疾病的严重程度。支气管扩张剂强制呼气量在1秒内除以强制生命能力（FEV_1 / FVC）<0.70的比例是COPD（1）诊断的经典截止。随着FEV_1 / FVC比率降低，疾病的严重程度增加。根据全球慢性阻塞性肺病（金）分类（1），普遍接受的COPD严重程度分类为患者分为四个阶段。我们可以根据在体内直接观察的肺部改变方面做出更好的方法来评估疾病吗？

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  • 来源
    《Academic radiology》 |2013年第5期|共2页
  • 作者

    BrownR.H.;

  • 作者单位

    Departments of Anesthesiology Radiology Medicine and Environmental Health Sciences Johns Hopkins;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 放射医学;
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