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Prediction and Reduction of Motion Artifacts in Free-Breathing Dynamic Contrast Enhanced CT Perfusion Imaging of Primary and Metastatic Intrahepatic Tumors

机译:自由呼吸动态造影中运动伪影的预测和减少增强的原发性和转移性肝内肿瘤的CT灌注成像

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摘要

Rationale and Objective: To develop and evaluate a method for predicting and reducing motion artifacts in free-breathing liver perfusion computed tomography (CT) scanning with couch shuttling and to compare tumor and liver parenchyma perfusion values. Materials and Methods: Thirty patients (23 males, 7 females, median age of 74 years) with primary or metastatic intrahepatic tumors underwent dynamic contrast enhanced CT scans with axial shuttling. A semiautomatic respiratory motion correction algorithm was applied to align the acquired images along the z-axis. Perfusion maps were generated using the dual-input Johnson-Wilson model. Root mean squared deviation (RMSD) maps of the model fit to the pixel time-density curves were calculated. Results: Precorrection RMSD correlated positively with magnitude of change in functional values resulting from motion. Blood flow, arterial blood flow, and permeability surface product were significantly increased in tumor compared to normal tissue (P <.05), blood volume was significantly reduced in tumor compared to normal tissue (P <.05). In a subgroup of patients with high-amplitude motion significant difference was observed between uncorrected and motion correction blood flow maps. Conclusions: Patients can breathe freely during hepatic perfusion imaging if retrospective motion correction is applied to reduce motion artifacts. RMSD provides a regional assessment of motion induced artifacts in liver perfusion maps.
机译:理由和目的:开发和评估用沙发梭扫描的自由呼吸肝灌注计算机断层扫描(CT)扫描的预测和减少动作伪影的方法,并比较肿瘤和肝实质灌注值。材料和方法:30名患者(23名男性,7名女性,74岁的中位数)具有原发性或转移性肝内肿瘤的动态对比增强CT扫描随着轴向梭扫描。应用半自动呼吸运动校正算法以沿Z轴对准所获取的图像。使用双输入约翰逊-Wilson模型生成灌注图。计算拟合对像素时间密度曲线的模型的根平均平方偏差(RMSD)映射。结果:预腐蚀RMSD在动作产生的功能值的变化幅度正相关。与正常组织相比,肿瘤中血流,动脉血流和渗透性表面产品显着增加(P <.05),与正常组织相比,肿瘤的血容量显着降低(P <.05)。在未校正和运动校正血流图之间观察到高幅度运动患者的亚组中。结论:如果施用回顾运动校正,则患者在肝灌注成像期间可以自由呼吸,以减少运动伪影。 RMSD提供了对肝灌注图中运动诱导的伪影的区域评估。

著录项

  • 来源
    《Academic radiology》 |2013年第4期|共9页
  • 作者单位

    Department of Physics and Astronomy University of Western Ontario 1151 Richmond Street London;

    Department of Physics and Astronomy University of Western Ontario 1151 Richmond Street London;

    Department of Oncology University of Western Ontario 1151 Richmond Street London ON N6A 3K7;

    Radiology St. Joseph's Health Care London ON Canada;

    Imaging Research Lab Robarts Research Institute London ON Canada;

    Department of Oncology University of Western Ontario 1151 Richmond Street London ON N6A 3K7;

    Department of Physics and Astronomy University of Western Ontario 1151 Richmond Street London;

    Department of Oncology University of Western Ontario 1151 Richmond Street London ON N6A 3K7;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 放射医学;
  • 关键词

    Computer-assisted; Hepatocellular carcinoma; Image processing; Liver; Liver circulation; Perfusion imaging;

    机译:计算机辅助;肝细胞癌;图像处理;肝脏;肝循环;灌注成像;

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