• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Academic radiology >Minimum detectable change in lung nodule volume in a phantom ct study
【24h】

Minimum detectable change in lung nodule volume in a phantom ct study

机译：Phantom CT研究中肺结核体积的最小可检测变化

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Rationale and Objectives: The change in volume of lung nodules is being examined as a measure of response to treatment. The aim ofthis study was to determine the minimum detectable change in nodule volume with the use of computed tomography. Materials and Methods: Four different layouts of synthetic nodules with different shapes but with the same size (5, 8, 9, or 10mm) for each layout were placed within an anthropomorphic phantom and scanned with a 16-detector-row computed tomography scanner using multiple imaging parameters. Nodule volume estimates were determined using a previously developed matched-filter estimator. Analysis of volume change was then conducted as a detection problem. For each nodule size, the pooled distribution of volume estimates was shifted by a percentage c to simulate a changing nodule, while accounting for standard deviation. The value of c resulting in a prespecified area under the receiver operating characteristic curve (AUC) was deemed the minimum detectable change for that AUC value. Results: Both nodule size at baseline and choice of slice collimation protocol had an effect on the value of minimum detectable growth. For AUC=0.95, the minimum detectable nodule growth in volume when using the thin-slice collimation protocol (16×0.75mm) was 17%, 19%, and 15% for nodule sizes of 5, 8, and 9mm, respectively. Conclusions: Our results indicate that an approximate bound for detectable nodule growth in subcentimeter nodules may be relatively small, on the order of 20% or less in volume for a thin-slice CT acquisition protocol.
机译：理由和目标：正在检查肺结节量的变化作为对治疗的反应的衡量标准。本研究的目的是通过使用计算断层扫描来确定结节体积的最小可检测变化。材料和方法：将每个布局与不同形状（5,8,9，或10mm）的合成结节的四种不同布局置于拟蒽型虚拟体内，并用16探测器排扫描扫描仪扫描多重成像参数。使用先前显影的匹配滤波器估计器确定结节音量估计。然后进行体积变化分析作为检测问题。对于每个结节大小，汇总估计的汇总分布被百分比C移位以模拟变化的结节，同时占标准偏差。导致接收器操作特征曲线（AUC）下的预定区域的C值被认为是该AUC值的最小可检测变化。结果：基线的结节尺寸和切片准直方案的选择对最小可检测生长的值具有效果。对于AUC = 0.95，使用薄片准直方案（16×0.75mm）时，体积的最小可检测结节生长分别为5,8和9mm的结节尺寸为17％，19％和15％。结论：我们的结果表明，薄切片CT采集协议的薄片CT采集协议的尺寸为20％以下的近似较小的可检测结节生长的近似束缚。

著录项

  • 来源
    《Academic radiology》 |2013年第11期|共7页
  • 作者

    GavrielidesM.A.; LiQ.; ZengR.; MyersK.J.; SahinerB.; PetrickN.;

  • 作者单位

    Division of Imaging and Applied Mathematics Office of Science and Engineering Laboratories Center;

    Division of Imaging and Applied Mathematics Office of Science and Engineering Laboratories Center;

    Division of Imaging and Applied Mathematics Office of Science and Engineering Laboratories Center;

    Division of Imaging and Applied Mathematics Office of Science and Engineering Laboratories Center;

    Division of Imaging and Applied Mathematics Office of Science and Engineering Laboratories Center;

    Division of Imaging and Applied Mathematics Office of Science and Engineering Laboratories Center;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 放射医学;
  • 关键词

    Detectable change; Lung nodule; Nodule; Phantom study; Treatment response; Volumetric computed tomography;

    机译：可检测的变化;肺结节;结节;幻影研究;治疗响应;体积计算断层扫描;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号