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首页> 外文期刊>Acta biomaterialia >Bioactive polymer grafting onto titanium alloy surfaces.
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Bioactive polymer grafting onto titanium alloy surfaces.

机译：生物活性聚合物嫁接到钛合金表面上。

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Bioactive polymers bearing sulfonate (styrene sodium sulfonate, NaSS) and carboxylate (methylacrylic acid, MA) groups were grafted onto Ti6Al4V alloy surfaces by a two-step procedure. The Ti alloy surfaces were first chemically oxidized in a piranha solution and then directly subjected to radical polymerization at 70 degrees C in the absence of oxygen. The grafted surfaces were characterized by X-ray photoelectron spectroscopy (XPS), time-of-flight secondary ion mass spectrometry (ToF-SIMS) and the toluidine blue colorimetric method. Toluidine blue results showed 1-5microgcm(-2) of polymer was grafted onto the oxidized Ti surfaces. Grafting resulted in a decrease in the XPS Ti and O signals from the underlying Ti substrate and a corresponding increase in the XPS C and S signals from the polymer layer. The ToF-SIMS intensities of the S(-) and SO(-) ions correlated linearly with the XPS atomic percent S concentrations and the ToF-SIMS intensity of the TiO(3)H(2)(-) ion correlated linearly with the XPS atomic per cent Ti concentration. Thus, the ToF-SIMS S(-), SO(-) and TiO(3)H(2)(-) intensities can be used to quantify the composition and amount of grafted polymer. ToF-SIMS also detected ions that were more characteristic of the polymer molecular structure (C(6)H(4)SO(3)(-) and C(8)H(7)SO(3)(-) from NaSS, C(4)H(5)O(2)(-) from MA), but the intensity of these peaks depended on the polymer thickness and composition. An in vitro cell culture test was carried out with human osteoblast-like cells to assess the influence of the grafted polymers on cell response. Cell adhesion after 30min of incubation showed significant differences between the grafted and ungrafted surfaces. The NaSS grafted surfaces showed the highest degree of cell adhesion while the MA-NaSS grafted surfaces showed the lowest degree of cell adhesion. After 4 weeks in vivo in rabbit femoral bones, bone was observed to be in direct contact with all implants. The percentage of mineralized tissue around the implants was similar for NaSS grafted and non-grafted implants (59% and 57%). The MA-NaSS grafted implant exhibited a lower amount of mineralized tissue (47%).
机译：将亚磺酸酯（苯乙烯磺酸钠，NASS）和羧酸酯（甲基丙烯酸，MA）通过两步的方法接枝生物活性聚合物。首先将Ti合金表面在比拉兰溶液中化学氧化，然后在没有氧的情况下直接在70℃下直接进行自由基聚合。接枝表面的特征在于X射线光电子能谱（XPS），飞行时间二次离子质谱（TOF-SIMS）和甲苯胺蓝色比色法。甲苯胺蓝结果显示将1-5microgcm（-2）聚合物移植到氧化的Ti表面上。嫁接导致XPS Ti和来自底层Ti衬底的信号的减少和来自聚合物层的XPS C和S信号的相应增加。 S（ - ）等（ - ）离子的TOF-SIMS强度与XPS原子百分比的浓度线性相关，TIO（3）H（2）（ - ）离子的TOO-SIMS强度与线性相关联XPS原子％百分之浓度。因此，可以使用TOF-SIMS S（ - ），SO（ - ）和TiO（3）H（2）（ - ）强度来量化接枝聚合物的组成和量。 TOF-SIMS还检测到聚合物分子结构（C（6）H（4）所以（3）（ - ）和C（8）H（7）H（3）（ - ）来自NASS的离子， C（4）H（5）O（2）（ - ）来自MA），但这些峰的强度依赖于聚合物厚度和组成。将体外细胞培养试验用人成骨细胞样细胞进行，以评估接枝聚合物对细胞反应的影响。 30分钟孵育后的细胞粘附在接枝和未移植的表面之间显示出显着的差异。 NASS接枝表面显示出最高程度的电池粘附，而MA-NASS接枝表面显示出最低的电池粘附程度。在兔股骨骨骼的体内4周后，观察到骨骼与所有植入物直接接触。植入物周围的矿化组织的百分比类似于NASS接枝和非接枝植入物（59％和57％）。 MA-NASS接枝植入物表现出较低的矿化组织（47％）。

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