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首页> 外文期刊>Acta biomaterialia >In situ generation of sodium alginate/hydroxyapatite nanocomposite beads as drug-controlled release matrices.
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In situ generation of sodium alginate/hydroxyapatite nanocomposite beads as drug-controlled release matrices.

机译：原位产生藻酸钠/羟基磷灰石纳米复合珠作为药物控制释放基质。

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摘要

In order to find a new way to slow down the release of drugs and to solve the burst release problem of drugs from traditionally used hydrogel matrices, a series of novel pH-sensitive sodium alginate/hydroxyapatite (SA/HA) nanocomposite beads was prepared by the in situ generation of HA micro-particles in the beads during the sol-gel transition process of SA. The SA/HA nanocomposites were characterized by Fourier transform IR spectroscopy, X-ray fluorescence spectrometry, scanning electron microscopy and field emission SEM in order to reveal their composition and surface morphology as well as the role that the in situ generated HA micro-particles play. The factors influencing the swelling behavior, drug loading and controlled release behavior of the SA/HA nanocomposite beads were also investigated using diclofenac sodium (DS) as the model drug. The HA micro-particles act as inorganic crosslinkers in the nanocomposites, which could contract and restrict the movability of the SA polymer chains, and then change the surface morphology and decrease the swell ratio. Meanwhile, the entrapment efficiency of DS was improved, and the burst release of DS was overcome. The factors (including concentration of Ca(2+), reaction time and temperature) affecting the growth of HA micro-particles have a clear influence on the entrapment efficiency and release rate of DS. In this work, the nanocomposite beads prepared under optimum condition could prolong the release of DS for 8h more compared with the pristine SA hydrogel beads.
机译：为了找到一种缓慢释放药物的新方法，并解决来自传统使用的水凝胶基质的药物的爆发释放问题，通过SA的溶胶 - 凝胶过渡过程中珠子中HA微粒的原位产生。 SA / HA纳米复合材料的特征在于傅里叶变换IR光谱，X射线荧光光谱法，扫描电子显微镜和场排放SEM，以揭示其组成和表面形态以及原位生成的HA微粒发挥作用的作用。使用双氯芬酸钠（DS）作为模型药物，还研究了影响SA / HA纳米复合珠的肿胀行为，药物载荷和控释行为的因素。 HA微粒作为纳米复合材料中的无机交联剂，其可以收缩和限制SA聚合物链的可加工性，然后改变表面形态并降低溶胀比。同时，改善了DS的夹带效率，克服了DS的爆发释放。影响HA微粒生长的因素（包括Ca（2+），反应时间和温度的浓度，对DS的夹带效率和释放速率有明显的影响。在这项工作中，与原始SA水凝胶珠子相比，在最佳条件下制备的纳米复合珠可以延长DS的释放8小时。

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