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首页> 外文期刊>Acta biomaterialia >Superhydrophobic, nanotextured polyvinyl chloride films for delaying Pseudomonas aeruginosa attachment to intubation tubes and medical plastics
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Superhydrophobic, nanotextured polyvinyl chloride films for delaying Pseudomonas aeruginosa attachment to intubation tubes and medical plastics

机译：超疏水，纳米纹理聚氯乙烯薄膜，用于延迟铜绿假单胞菌附着于插管管和医用塑料

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摘要

Bacterial attachment onto the surface of polymers in medical devices such as polyvinyl chloride (PVC) is influenced by the physicochemical properties of the polymer, including its surface hydrophobicity and roughness. In this study, to prevent biofilm formation onto PVC devices, the PVC surface was modified using a combination of solvent (tetrahydrofuran) and non-solvents (i.e. ethanol and methanol). The surface of unmodified PVC was smooth and relatively hydrophobic (water contact angle (CA) = 80°). Ethanol-treated PVCs revealed the presence of micron-sized particulates and porous structures as the concentration of ethanol was increased. Surface hydrophobicity (measured in terms of CA) increased from 73° to 150° as the ethanol concentration increased from 15% to 35% (v/v). In general, methanol-treated PVCs were more hydrophilic compared to those treated with ethanol. The colonization of Pseudomonas aeruginosa PAO1 onto unmodified PVC surface was rapid, and individual bacterial cells could be seen after 6 h incubation. On the surface of treated PVC, the secretion of extracellular matrix layers was evident at 18 h and P. aeruginosa PAO1 start to form microcolonies at 24 h of incubation. The initial attachment of P. aeruginosa PAO1 was delayed to 18 and 24 h, respectively in the PVCs treated with 25% (v/v) and 35% (v/v) ethanol. It can be concluded that the treatment used in this study to prepare superhydrophobic PVC surface prevented the colonization of bacteria up to 24 h after culture.
机译：在诸如聚氯乙烯（PVC）之类的医疗装置中的聚合物表面上的细菌附着受到聚合物的物理化学性质的影响，包括其表面疏水性和粗糙度。在该研究中，为了防止生物膜形成在PVC器件上，使用溶剂（四氢呋喃）和非溶剂的组合来改变PVC表面（即乙醇和甲醇）。未改性PVC的表面光滑且相对疏水（水接触角（CA）= 80°）。乙醇处理的PVC显示出在乙醇浓度增加时存在微米尺寸的颗粒和多孔结构。随着乙醇浓度从15％增加到35％（v / v），表面疏水性从73°至150°增加增加到150°。通常，与用乙醇处理的那些相比，甲醇处理的PVC更亲水。将假单胞菌铜绿假单胞菌PAO1的定植到未修饰的PVC表面上是快速的，并且在6小时孵育后可以看到各种细菌细胞。在处理过的PVC表面上，在18小时和P. Aeruginosa Pao1开始在孵育24小时时开始细胞外基质层的分泌。 P.铜绿假单胞菌PAO1的初始附着分别在用25％（v / v）和35％（v / v）乙醇处理的PVC中延迟至18和24小时。可以得出结论，本研究中使用的治疗方法制备超疏水PVC表面，防止了培养后24小时的细菌定植。

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