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首页> 外文期刊>Acta biomaterialia >Multifunctional polymeric microfibers with prolonged drug delivery and structural support capabilities
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Multifunctional polymeric microfibers with prolonged drug delivery and structural support capabilities

机译：多官能聚合物微纤维，具有延长的药物递送和结构支持能力

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摘要

The strength and stability of hybrid fiber delivery systems, ones that perform a mechanical function and simultaneously deliver drug, are critical in the design of surgically implantable constructs. We report the fabrication of drug-eluting microfibers where drug loading and processing conditions alone increase microfiber strength and stability partially due to solvent-induced crystallization. Poly(l-lactic acid) microfibers of 64 ± 7 μm diameter were wet spun by phase inversion. Encapsulation of a model hydrophobic anti-inflammatory drug, dexamethasone, at high loading provided stability to microfibers which maintained linear cumulative release kinetics up to 8 weeks in vitro. In our wet spinning process, all microfibers had increased crystallinity (13-17%) in comparison to unprocessed polymer without any mechanical stretching. Moreover, microfibers with the highest drug loading retained 97% of initial tensile strength and were statistically stronger than all other microfiber formulations, including control fibers without drug. Results indicate that the encapsulation of small hydrophobic molecules (<400 Da) may increase the mechanical integrity of microfilaments whose crystallinity is also increased as a result of the process. Multifunctional drug-eluting microfibers can provide an exciting new opportunity to design novel biomaterials with mechanical stability and controlled release of a variety of therapeutics with micron-scale accuracy.
机译：混合纤维输送系统的强度和稳定性，具有机械功能和同时递送药物的稳定性在外科植入构建体的设计中至关重要。我们报告了药物洗脱微纤维的制备，其中药物负载和加工条件仅通过溶剂诱导的结晶而部分地增加微纤维强度和稳定性。聚（L-乳酸）直径为64±7μm的微纤维通过相倒反应湿式旋转。在高负载下封装模型疏水性抗炎药，地塞米松，为微纤维提供了稳定性，其在体外保持线性累积释放动力学长达8周。在我们的湿纺过程中，与未加工的聚合物相比，所有微纤维的结晶度（13-17％）升高而没有任何机械拉伸。此外，具有最高药物负载的微纤维保留了97％的初始拉伸强度，并且比所有其他微纤维配方统计学更强，包括没有药物的对照纤维。结果表明，小型疏水分子（<400da）的包封可以增加由于该方法的结晶度也增加的微细丝的机械完整性。多功能药物洗脱的微纤维可以提供令人兴奋的新机会，可以设计具有机械稳定性的新型生物材料，并以微米级精度控制各种治疗剂的控制释放。

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