• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Acta biomaterialia >A complex of cyclohexane-1,2-diaminoplatinum with an amphiphilic biodegradable polymer with pendant carboxyl groups
【24h】

A complex of cyclohexane-1,2-diaminoplatinum with an amphiphilic biodegradable polymer with pendant carboxyl groups

机译：与侧链羧基的两亲可生物降解聚合物的环己烷-1,2-二氨基铂的复合物

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

A biodegradable and amphiphilic copolymer, MPEG-b-P(LA-co-MCC), which contains pendant carboxyl groups, was chosen as a drug carrier for the active anticancer part (DACH-Pt) of oxaliplatin to form an MPEG-b-P(LA-co-MCC/Pt) complex. It was able to self-assemble into micelles with a mean diameter of 30-40 nm, and a surface potential near -10 mV. The typical platinum content was 10 wt.%. The micelles showed acid-responsive drug release kinetics, which is beneficial for drug release in the intracellular environment. The Pt(II) species were released mainly in the form of DACH-Pt-Cl 2 in 150 mM NaCl solution and DACH-Pt 2+-(H 2O) 2 in pure water according to the results obtained by high-performance liquid chromatography coupled with inductively coupled plasma mass spectrometry and X-ray photoelectron spectroscopy. In vitro evaluation showed that the micelles displayed the same or higher cytotoxicities against SKOV-3, HeLa, and EC-109 cancer cells compared with oxaliplatin. The enhanced cytotoxicity against SKOV-3 cells is attributed to effective internalization of the micelles by the cells via endocytosis and the sensitivity of SKOV-3 cells to platinum drugs. This novel biodegradable and amphiphilic copolymer-based platinum drug will have great potential application in clinical use.
机译：含有侧链羧基的可生物降解和两亲共聚物，MPEG-BP（LA-CO-MCC）被选择为奥沙利铂的活性抗癌部分（DACH-PT）以形成MPEG-BP的药物载体（LA- CO-MCC / PT）复合物。它能够自组装成胶束，平均直径为30-40nm，表面电位接近-10 mV。典型的铂含量为10重量％。％。胶束显示出酸性响应药物释放动力学，这对于细胞内环境中的药物释放有益。 Pt（II）物种主要以150mM NaCl溶液和纯水中的150mM NaCl溶液和DACH-PT 2 + - （H 2 O）2的形式释放，所述纯水中通过高效液相色谱法获得的结果耦合电感耦合等离子体质谱和X射线光电子谱。体外评估表明，与奥沙利铂相比，胶束展示了对SkoV-3，Hela和EC-109癌细胞的相同或更高的细胞毒性。对SkoV-3细胞的增强细胞毒性归因于通过内吞作用和SkoV-3细胞对铂药的敏感性的细胞有效内化。这种新型的可生物降解和两亲共聚物的铂药物将在临床使用中具有很大的潜在应用。

著录项

  • 来源
    《Acta biomaterialia》 |2012年第5期|共10页
  • 作者

    XiaoH.; ZhouD.; LiuS.; ZhengY.; HuangY.; JingX.;

  • 作者单位

    State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied Chemistry;

    State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied Chemistry;

    State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied Chemistry;

    State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied Chemistry;

    State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied Chemistry;

    State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied Chemistry;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 普通生物学;
  • 关键词

    Cancers; Micelles; Oxaliplatin; Polymer-drug conjugate; Pro-drug;

    机译：癌症;胶束;oxaliplatin;聚合物 - 药物缀合物;药物;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号