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首页> 外文期刊>Acta biomaterialia >Osteoclast resorption of thermal spray hydoxyapatite coatings is influenced by surface topography
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Osteoclast resorption of thermal spray hydoxyapatite coatings is influenced by surface topography

机译：热喷雾瓦羟磷灰石涂层的骨壳再吸收受表面形貌的影响

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摘要

Coating characteristics such as composition, crystallite features and topography collectively impact the cell response. The influence from splats has not yet been assessed for hydroxyapatite (HAp) thermal spray coatings. The objective of this work is to (a) survey the topography on commercial implants, (b) ascertain topography formation from single splats, and (c) determine the osteoclast resorption pattern on a topographically refined coating compared to dentine. Coatings on dental implants, an orthopedic screw, a femoral stem and a knee implant were studied for reference. The effects of substrate pre-heat, roughness, spray distance and particle size on the coating roughness and topography were studied. Human-derived osteoclasts were placed on a coating with refined topography and compared to dentine, a polished coating and polished sintered HAp. A pre-heat of at least 200 °C on titanium was required to form rounded splats. The greatest influence on coating roughness and topography arose from particle size. A 2-fold increase in the mean particle size from 30 to 72 μm produced a significant difference (P < 0.001) in roughness from 4.8 and 9.7 μm. A model is shown to illustrate topography formation, nanostructure evolution on single splats, and the topography as seen in commercial implants. Osteoclasts showed a clear preference for activity on coatings with refined topography. A one-way ANOVA test revealed a significantly greater pit depth (P = 0.022) for dentine (14 μm) compared to the as-sprayed and polished coating (5 μm). Coatings with topography display a similar number of resorption pits with dentine, but a 10-fold greater number than polished coatings, emphasizing the importance of flattened droplet topography on implant surfaces.
机译：涂层特性如组成，微晶特征和地形共同影响细胞反应。尚磷灰石（HAP）热喷涂涂层尚未评估Splats的影响。这项工作的目的是（a）调查商业植入物的地形，（b）从单苜蓿中确定的地形形成，（c）与牙本质相比，确定了拓扑精制涂层上的破骨细胞吸收模式。研究了牙科植入物，矫形螺钉，股骨杆和膝关节植入物。研究了基材预热，粗糙度，喷射距离和粒度对涂层粗糙度和地形的影响。将人源性的骨质增料置于具有精制形貌的涂层上，并与牙本质，抛光涂层和抛光烧结的Hap相比。需要在钛上至少200℃的预热以形成圆形的Splats。对涂层粗糙度和地形的影响最大的影响来自粒度。平均粒径为30至72μm的2倍的增加产生的粗糙度（p <0.001），粗糙度为4.8和9.7μm。示出了一种模型来说明单苜蓿的形貌形成，纳米结构演变，以及商业植入物中所示的地形。骨核糖籽表明，在具有精制形貌的涂层上的活性偏好。与喷涂和抛光涂层（5μm）相比，单向ANOVA测试显示牙本质（14μm）的明显更大的凹坑深度（P = 0.022）。具有地形的涂层显示与牙本质相似的吸收坑，但比抛光涂层更大的10倍，强调扁平滴地在植入物表面上的重要性。

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