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首页> 外文期刊>Acta biomaterialia >Melt-spun shaped fibers with enhanced surface effects: fiber fabrication, characterization and application to woven scaffolds.
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Melt-spun shaped fibers with enhanced surface effects: fiber fabrication, characterization and application to woven scaffolds.

机译：熔纺成形纤维具有增强的表面影响：纤维制造，表征和应用于编织支架。

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Scaffolds with a high surface-area-to-volume ratio (SA:V) are advantageous with regard to the attachment and proliferation of cells in the field of tissue engineering. This paper reports on the development of novel melt-spun fibers with a high SA:V, which enhanced the surface effects of a fiber-based scaffold while maintaining its mechanical strength. The cross-section of the fibers was altered to a non-circular shape, producing a higher SA:V for a similar cross-sectional area. To obtain fibers with non-circular cross-sectional shape, or shaped fibers, three different types of metal spinnerets were fabricated for the melt-spinning process, each with circular, triangular or cruciform capillaries, using deep X-ray lithography followed by nickel electroforming. Using these spinnerets, circular and shaped fibers were manufactured with biodegradable polyester, polycaprolactone. The SA:V increase in the shaped fibers was experimentally investigated under different processing conditions. Tensile tests on the fibers and indentation tests on the woven fiber scaffolds were performed. The tested fibers and scaffolds exhibited similar mechanical characteristics, due to the similar cross-sectional area of the fibers. The degradation of the shaped fibers was notably faster than that of circular fibers, because of the enlarged surface area of the shaped fibers. The woven scaffolds composed of the shaped fibers significantly increased the proliferation of human osteosarcoma MG63 cells. This approach to increase the SA:V in shaped fibers could be useful for the fabrication of programmable, biodegradable fiber-based scaffolds in tissue engineering.
机译：具有高表面积到体积比（SA：V）的支架在组织工程领域中的细胞附着和增殖是有利的。本文报道了具有高SA：V的新型熔纺纤维的开发，其增强了纤维基支架的表面效应，同时保持其机械强度。纤维的横截面被改变为非圆形形状，产生更高的SA：V，用于类似的横截面积。为了获得具有非圆形横截面形状或成型纤维的纤维，为熔融纺丝工艺制造了三种不同类型的金属喷丝腺，每种用圆形，三角形或十字花毛细管，使用深X射线光刻，然后是镍电铸。使用这些喷丝头，用可生物降解的聚酯，聚己内酯制造圆形和成型纤维。在不同的加工条件下通过实验研究了SA：V成形纤维的增加。进行纤维上的拉伸试验和编织纤维支架上的压痕试验。由于纤维的相似横截面积，测试的纤维和支架表现出类似的机械特性。由于成形纤维的放大的表面积，成形纤维的劣化比圆形纤维的劣化更快。由成形纤维组成的编织支架显着增加了人骨骨膜Mg63细胞的增殖。这种增加SA的方法：V成形纤维可用于制造组织工程中的可编程可生物降解的纤维基支架。

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