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首页> 外文期刊>Acta biomaterialia >Bioactive self-assembled peptide nanofibers for corneal stroma regeneration
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Bioactive self-assembled peptide nanofibers for corneal stroma regeneration

机译：用于角膜基质再生的生物活性自组装肽纳米纤维

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摘要

Defects in the corneal stroma caused by trauma or diseases such as macular corneal dystrophy and keratoconus can be detrimental for vision. Development of therapeutic methods to enhance corneal regeneration is essential for treatment of these defects. This paper describes a bioactive peptide nanofiber scaffold system for corneal tissue regeneration. These nanofibers are formed by self-assembling peptide amphiphile molecules containing laminin and fibronectin inspired sequences. Human corneal keratocyte cells cultured on laminin-mimetic peptide nanofibers retained their characteristic morphology, and their proliferation was enhanced compared with cells cultured on fibronectin-mimetic nanofibers. When these nanofibers were used for damaged rabbit corneas, laminin-mimetic peptide nanofibers increased keratocyte migration and supported stroma regeneration. These results suggest that laminin-mimetic peptide nanofibers provide a promising injectable, synthetic scaffold system for cornea stroma regeneration.
机译：由神经角膜营养不良和角膜型疾病如神经角膜或疾病引起的角膜基质中的缺陷可能对视力有害。提高角膜再生的治疗方法的发展对于治疗这些缺陷至关重要。本文描述了一种用于角膜组织再生的生物活性肽纳米纤维支架系统。这些纳米纤维是通过含有层粘蛋白和纤连蛋白的自组装肽两亲分子形成的。在层膜模拟肽纳米纤维上培养的人角膜角膜织物细胞保留其特征形态，与在纤维素 - 模拟纳米纤维上培养的细胞相比，它们的增殖增强。当这些纳米纤维用于受损的兔角膜时，层导蛋白模拟肽纳米纤维增加了角膜细胞迁移和负载基质再生。这些结果表明，层膜模拟肽纳米纤维提供了用于角膜基质再生的有希望的可注射的合成支架系统。

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  • 来源
    《Acta biomaterialia》 |2014年第3期|共11页
  • 作者

    UzunalliG.; SoranZ.; ErkalT.S.; DagdasY.S.; DincE.; HondurA.M.; BilgihanK.; AydinB.; GulerM.O.; TekinayA.B.;

  • 作者单位

    Institute of Materials Science and Nanotechnology National Nanotechnology Research Center (UNAM);

    Institute of Materials Science and Nanotechnology National Nanotechnology Research Center (UNAM);

    Institute of Materials Science and Nanotechnology National Nanotechnology Research Center (UNAM);

    Institute of Materials Science and Nanotechnology National Nanotechnology Research Center (UNAM);

    Department of Ophthalmology School of Medicine Mersin University Mersin Turkey;

    Department of Ophthalmology Gazi University Ankara Turkey;

    Department of Ophthalmology Gazi University Ankara Turkey;

    Department of Ophthalmology Gazi University Ankara Turkey;

    Institute of Materials Science and Nanotechnology National Nanotechnology Research Center (UNAM);

    Institute of Materials Science and Nanotechnology National Nanotechnology Research Center (UNAM);

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 普通生物学;
  • 关键词

    Corneal stroma regeneration; Peptide amphiphile; RGD; Self-assembly; YIGSR;

    机译：角膜基质再生;肽两亲物;RGD;自我组装;yigsr;

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