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首页> 外文期刊>Acta biomaterialia >Fabrication of quercetin and curcumin bionanovesicles for the prevention and rapid regeneration of full-thickness skin defects on mice
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Fabrication of quercetin and curcumin bionanovesicles for the prevention and rapid regeneration of full-thickness skin defects on mice

机译：槲皮素和姜黄素脱硫的制备用于预防和快速再生的小鼠全厚皮肤缺陷

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摘要

In the present work biocompatible quercetin and curcumin nanovesicles were developed as a novel approach to prevent and restore skin tissue defects on chronic cutaneous pathologies. Stable and suitable quercetin- and curcumin-loaded phospholipid vesicles, namely liposomes and penetration enhancer-containing vesicles (PEVs), were prepared. Vesicles were made from a highly biocompatible mixture of phospholipids and alternatively a natural polyphenol, quercetin or curcumin. Liposomes were obtained by adding water, while PEVs by adding polyethylene glycol 400 and Oramix?CG110 to the water phase. Transmission electron microscopy, cryogenic-transmission electron microscopy and small- and wide-angle X-ray scattering showed that vesicles were spherical, oligo- or multilamellar and small in size (112-220 nm). In vitro and in vivo tests underlined a good effectiveness of quercetin and curcumin nanovesicles in counteracting phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) induced lesions and inflammation. Myeloperoxydase activity, used to gauge inflammation, was markedly inhibited by quercetin liposomes (59%) and curcumin liposomes and polyethylene glycol (PEG)-PEVs (～68%). Histology showed that PEG-PEVs provided an extensive re-epithelization of the TPA-damaged skin, with multiple layers of thick epidermis. In conclusion, nanoentrapped polyphenols prevented the formation of skin lesions abrogating the various biochemical processes that cause epithelial loss and skin damage.
机译：在本工作中，生物相容性槲皮素和姜黄素纳米粒子被开发为一种预防和恢复慢性皮肤病理学对皮肤组织缺陷的新方法。制备稳定和合适的槲皮素和姜黄素和姜黄素的磷脂囊泡，即脂质体和含渗透性增强剂的囊泡（PEVS）。囊泡由高度生物相容性的磷脂混合物制成，也是天然多酚，槲皮素或姜黄素。通过加入水而获得脂质体，而通过将聚乙二醇400和奥克拉姆·βcG110加入水相而获得。透射电子显微镜，低温透射电子显微镜和小型和广角X射线散射表明，囊泡是球形，寡核苷酸，少于尺寸和小（112-220nm）。体外和体内试验在抵抗菲尔博酯12-O-四癸酰卟啉-13-乙酸盐（TPA）诱导的病变和炎症中强调槲皮素和姜黄素纳米粒子的良好有效性。用来测量炎症的Myeloceroxydase活性被槲皮素脂质体（59％）和姜黄素脂质体和聚乙二醇（PEG）-PEVs（〜68％）显着抑制。组织学表明，PEG-PEVS提供了TPA受损皮肤的广泛重新上皮，具有多层厚表皮。总之，纳米级多酚防止了形成皮肤病变的形成，耗尽了引起上皮损失和皮肤损伤的各种生化过程。

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  • 来源
    《Acta biomaterialia》 |2014年第3期|共9页
  • 作者

    CastangiaI.; NácherA.; CaddeoC.; ValentiD.; FaddaA.M.; Díez-SalesO.; Ruiz-SauríA.; ManconiM.;

  • 作者单位

    Dept. Scienze della Vita e dell'Ambiente University of Cagliari Via Ospedale 72 09124 Cagliari;

    Dept. of Pharmacy and Pharmaceutical Technology University of Valencia Avda Vicente Andrés Estell;

    Dept. Scienze della Vita e dell'Ambiente University of Cagliari Via Ospedale 72 09124 Cagliari;

    Dept. Scienze della Vita e dell'Ambiente University of Cagliari Via Ospedale 72 09124 Cagliari;

    Dept. Scienze della Vita e dell'Ambiente University of Cagliari Via Ospedale 72 09124 Cagliari;

    Dept. of Pharmacy and Pharmaceutical Technology University of Valencia Avda Vicente Andrés Estell;

    Dept. of Pathology University of Valencia Avda Blasco Iba?ez 17 46010 Valencia Spain;

    Dept. Scienze della Vita e dell'Ambiente University of Cagliari Via Ospedale 72 09124 Cagliari;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 普通生物学;
  • 关键词

    Histopathology; Polyphenols; Skin inflammation; Vesicles; Wound healing;

    机译：组织病理学;多酚;皮肤炎症;囊泡;伤口愈合;

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