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首页> 外文期刊>Acta biomaterialia >Structure-property effects of novel bioresorbable hybrid structures with controlled release of analgesic drugs for wound healing applications
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Structure-property effects of novel bioresorbable hybrid structures with controlled release of analgesic drugs for wound healing applications

机译：伤口愈合应用对镇痛药物控制释放的新型生物可吸收杂交结构的结构性质效应

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Over the last decades, wound dressings have developed from the traditional gauze dressing to tissue-engineered scaffolds. A wound dressing should ideally maintain a moist environment at the wound surface, allow gas exchange, act as a barrier to micro-organisms and remove excess exudates. In order to provide these characteristics, we developed and studied bioresorbable hybrid structures which combine a synthetic porous drug-loaded top layer with a spongy collagen sublayer. The top layer, prepared using the freeze-drying of inverted emulsions technique, was loaded with the analgesic drugs ibuprofen or bupivacaine, for controlled release to the wound site. Our investigation focused on the effects of the emulsion's parameters on the microstructure and on the resulting drug-release profile, as well as on the physical and mechanical properties. The structure of the semi-occlusive top layer enables control over vapor transmission, in addition to strongly affecting the drug release profile. Release of the analgesic drugs lasted from several days to more than 100 days. Higher organic:aqueous phase ratios and polymer contents reduced the burst release of both drugs and prolonged their release due to a lower porosity. The addition of reinforcing fibers to this layer improved the mechanical properties. Good binding of the two components, PDLGA and collagen, was achieved due to our special method of preparation, which enables a third interfacial layer in which both materials are mixed to create an "interphase". These new PDLGA/collagen structures demonstrated a promising potential for use in various wound healing applications.
机译：在过去的几十年中，伤口敷料从传统的纱布敷料到组织工程脚手架。伤口敷料理想地应在伤口表面保持潮湿的环境，允许气体交换，作为微生物的屏障并去除过量的渗出物。为了提供这些特征，我们开发和研究了生物可吸收的混合结构，其将合成多孔药物装载的顶层与海绵状胶原蛋白子层组合。使用倒置乳液技术的冷冻干燥制备的顶层与镇痛药中的布洛芬或Bupivacaine加载，用于对伤口部位的控制释放。我们的研究侧重于乳液参数对微观结构和所得药物释放曲线的影响，以及物理和机械性能。除了强烈影响药物释放曲线之外，半闭塞式顶层的结构能够控制蒸汽传动。镇痛药的释放持续了几天到100多天。更高的有机：水相比和聚合物含量降低了两种药物的爆发释放，并由于孔隙率较低而延长其释放。加入该层的增强纤维改善了机械性能。由于我们的特殊制备方法，实现了两种组分，PDLGA和胶原蛋白的良好结合，这使得这两种材料被混合为“间间”的第三界面层。这些新的PDLGA /胶原蛋白结构证明了在各种伤口愈合应用中使用的有希望的潜力。

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