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Luminescent mesoporous nanoreservoirs for the effective loading and intracellular delivery of therapeutic drugs

机译：发光介孔纳米梭菌，用于治疗药物的有效载荷和细胞内递送

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摘要

Development of biocompatible and multifunctional nanocarriers is important for the therapeutic efficacy of drug molecules in the treatment of disease and tissue repair. A novel nanocarrier of luminescent hollowed mesoporous silica (L-hMS) was explored for the loading and controlled delivery of drugs. For the synthesis of L-hMS, self-activated luminescence hydroxyapatite (LHA) was used as a template. Different thicknesses (～7-62 nm) of mesoporous silica shell were obtained by varying the volume of silica precursor and the subsequent removal of the LHA core, which resulted in hollow-cored (size of ～40 nm × 10 nm) mesoporous silica nanoreservoirs, L-hMS. While the silica shell provided a highly mesoporous structure, enabling an effective loading of drug molecules, the luminescent property of LHA was also well preserved in both the silica-shelled and the hollow-cored nanocarriers. Doxorubicin (DOX), used as a model drug, was shown to be effectively loaded onto the mesopore structure and within the hollow space of the nanoreservoir. The DOX release was fairly pH-dependent, occurring more rapidly at pH 5.3 than at pH 7.4, and a long-term sustainable delivery over the test period of 2 weeks was observed. The nanoreservoir exhibited favorable cell compatibility with low cytotoxicity and excellent cell uptake efficiency (over 90%). Treatment of HeLa cells with DOX-loaded L-hMS elicited a sufficient degree of biological efficacy of DOX, as confirmed in the DOX-induced apoptotic behaviors, including stimulation in caspase-3 expression, and was even more effective than the direct DOX treatment. Overall, the newly developed L-hMS nanoreservoirs may be potentially useful as a multifunctional (luminescent, mesoporous and biocompatible) carrier system to effectively load and sustainably deliver small molecules, including anticancer drugs.
机译：生物相容性和多功能纳米载体的发展对于药物分子治疗疾病和组织修复中的治疗效果是重要的。探索了一种新的发光中空介孔二氧化硅（L-HMS）的纳米载体用于加载和受控的药物递送。对于L-HMS的合成，将自激化发光羟基磷灰石（LHA）用作模板。通过改变二氧化硅前体的体积和随后去除LHA核的体积而得到的不同厚度（〜7-62nm），导致中空芯（〜40nm×10nm的尺寸）的中孔二氧化硅纳米载体，l-hms。虽然二氧化硅壳提供高介孔结构，但能够有效地负载药物分子，但LHA的发光性能在二氧化硅壳和中空核心纳米载体中也得到很好的保存。显示用作模型药物的多柔比星（DOX），被证明有效地装载到中孔结构上并在纳米梭菌的中空空间内。 DOX释放相当pH依赖性，在pH 5.3时迅速发生，而不是pH 7.4，并且观察到2周的测试期间的长期可持续递送。纳米烃与低细胞毒性和优异的细胞摄取效率（超过90％）表现出良好的细胞相容性。用Dox-L-HMS处理HeLa细胞的HeLa细胞引发了DOX的足够的生物学效果，如在Dox诱导的凋亡行为中证实，包括在Caspase-3表达中刺激，并且比直接DOX处理更有效。总的来说，新开发的L-HMS纳米菌属可能是有效载荷和可持续地提供抗癌药物的多官能（发光，中孔和生物相容性）载体系统的潜在可用作多官能（发光，中孔和生物相容性）载体系统。

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  • 来源
    《Acta biomaterialia》 |2014年第3期|共12页
  • 作者

    KwonS.; SinghR.K.; KimT.-H.; PatelK.D.; KimJ.-J.; ChrzanowskiW.; KimH.-W.;

  • 作者单位

    Faculty of Pharmacy University of Sydney NSW 2006 Australia;

    Institute of Tissue Regeneration Engineering (ITREN) Dankook University Cheonan 330-714 South;

    Institute of Tissue Regeneration Engineering (ITREN) Dankook University Cheonan 330-714 South;

    Institute of Tissue Regeneration Engineering (ITREN) Dankook University Cheonan 330-714 South;

    Faculty of Pharmacy University of Sydney NSW 2006 Australia Institute of Tissue Regeneration;

    Faculty of Pharmacy University of Sydney NSW 2006 Australia;

    Institute of Tissue Regeneration Engineering (ITREN) Dankook University Cheonan 330-714 South;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 普通生物学;
  • 关键词

    Drug delivery; Hollow silica; Luminescent; Multifunctional; Nanocarrier;

    机译：药物递送;中空二氧化硅;发光;多功能;纳米载波;

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