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首页> 外文期刊>Acta biomaterialia >Prevention of infection in external fixator pin sites.
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Prevention of infection in external fixator pin sites.

机译：预防外固定器销位点感染。

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摘要

Infection in external fixator pins is known to be a significant problem, with incidences between 3% and 80% reported in the literature. An infection occurs when planktonic bacteria adhere to external fixator pins and subsequently produce a biofilm which protects the bacteria from host defences. The most commonly implicated organisms are Staphylococcus aureus and Staphylococcus epidermidis. Once an infection occurs, treatment is difficult. Systemic antibiotics have limited benefits and considerable side-effects. The only definitive management is removal of the pin. This review will consider the current and potential future strategies for reducing pin site infection. Techniques to prevent infection must prevent bacterial adhesion, allow good osteointegration and have a low toxicity. Current areas of interest reviewed are titanium-copper alloys, nanosilver coatings, nitric oxide coatings, chitosan coatings, chlorhexidine and iodine, hydroxyapatite and antibiotic coatings. At present there is no consensus on the prevention of pin site infection, and there is a paucity of randomized controlled trials on which to draw a conclusion. Whilst a number of these strategies have potential future use, many of the above strategies need further studies in animal models to ensure no cytotoxicity and prevention of osteointegration. Following this, well-designed randomized controlled clinical trials are required to give future ways to prevent external fixator pin site infections.
机译：众所周知，外固定器销中的感染是一个重要的问题，发病率在文献中报告了3％和80％。当浮游细菌粘附到外固定器销并随后产生保护细菌免受寄主防御的生物膜时，发生感染。最常用的有机体是金黄色葡萄球菌和葡萄球菌表皮。一旦感染发生，难以治疗。全身抗生素具有有限的益处和相当大的副作用。唯一的最终管理是拆除引脚。本综述将考虑减少销位点感染的当前和潜在的未来策略。预防感染的技术必须防止细菌粘附，允许良好的骨囊肿并具有低毒性。审查的当前感兴趣的区域是钛 - 铜合金，纳米玻璃涂层，一氧化氮涂料，壳聚糖涂料，氯己定和碘，羟基磷灰石和抗生素涂层。目前没有关于预防弓位点感染的共识，并且有一种可随机对照试验来得出结论。虽然许多这些策略具有潜在的未来使用，但上述许多策略需要进一步研究动物模型，以确保无细胞毒性和预防骨囊肿。在此之后，需要精心设计的随机对照临床试验，以提供防止外部固定器引脚位点感染的未来方法。

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