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首页> 外文期刊>Cytokine >The association of IL-8-251T/A polymorphism with complicated malaria in Karbi Anglong district of Assam
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The association of IL-8-251T/A polymorphism with complicated malaria in Karbi Anglong district of Assam

机译：IL-8-251T / A质量复杂疟疾的多态性的关联Assam

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Amongst host genetic factors, cytokine gene polymorphism can be anticipated to be an important factor as qualitative, quantitative and time of secretion play an important role in disease outcome. We have investigated association of cytokine promoter SNPs with risk of Plasmodium falciparum malaria and disease severity in a case control study in malaria endemic Karbi Anglong district of Assam, India.Frequency of IL-8-251T/A (p=0.03 and p=0.01) and TGF-β1-509C/T (p=0.02 and p=0.03) was higher in malaria in comparison to control participants and non-malarial fever controls. Interestingly, a higher frequency of mutant allele of IL-10-819T/C was observed in non-malarial fever controls compared to malaria thus suggesting its role as a distinguishing marker of the two disease groups. Higher IL-8 expression and increased frequency of IL-8-251T/A in complicated malaria (p=0.002) was reported indicating its role in susceptibility to complicated malaria.In conclusion, our study suggests the role of mutant genotype of IL-8-251T/A as a marker of complicated malaria in our population. Surprisingly, decreased expression of TGF-β1 in uncomplicated malaria even in presence of high expressing mutant genotype was observed and needs to be investigated in context of the pool of activated cells producing the cytokine.
机译：在宿主遗传因素中，可以预期细胞因子基因多态性是定性，定量和分泌时间在疾病结果中起重要作用的重要因素。我们研究了细胞因子启动子SNP与疟疾疟疾疟疾和疾病严重程度的风险，在印度阿萨姆阿萨姆·阿萨姆疟原虫区的病例对照研究中进行了疟疾和疾病严重程度。IL-8-251T / A的频率（P = 0.03和P = 0.01与控制参与者和非疟疾热量控制相比，疟疾的TGF-β1-509C/ T（p = 0.02和p = 0.03）较高。有趣的是，与疟疾相比，在非疟疾热量控制中观察到IL-10-819T / C的较高频率的突变等位基因，因此表明其作为两种疾病群体的显着标志物的作用。据报道，在复杂的疟疾（P = 0.002）中的较高IL-8表达和增加的IL-8-251T / A频率表明其在对复杂疟疾的易感性中的作用。在结论中，我们的研究表明IL-8突变基因型的作用-251t / a作为我们人口复杂疟疾的标志物。令人惊讶的是，即使存在高表达突变基因型的存在，也可以在不复杂的疟疾中降低TGF-β1的表达，并且需要在产生细胞因子的活性细胞库的背景下进行研究。

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