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首页> 外文期刊>Cytokine >Attenuation of adjuvant-induced arthritis in rats by phonophoresis with an aqueous gel of the Amazonian plant Elaeoluma nuda (Sapotaceae)
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Attenuation of adjuvant-induced arthritis in rats by phonophoresis with an aqueous gel of the Amazonian plant Elaeoluma nuda (Sapotaceae)

机译：亚麻植物含水凝胶凝胶凝胶凝胶蛋白酶凝胶（Sapotaceae）抑制大鼠辅助诱导的关节炎

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摘要

Background: Various species of the genus Pouteria (Elaeoluma) are used by the native population of Brazil because of, among other factors, their anti-inflammatory properties. The anti-inflammatory properties of the extract of the Amazonian plant Elaeoluma nuda were recently identified in prospective pharmacological studies. Objectives: The objective of this study was to assess the anti-inflammatory effect of phonophoresis with aqueous gel extract of E. nuda in rat adjuvant-induced arthritis. Methodology: Arthritis was induced in Lewis rats with an adjuvant. Phonophoresis with E. nuda gel was then administered daily and the results compared with those obtained with phonophoresis of diclofenac diethylammonium gel and ultrasound therapy without phonophoresis. Arthritis in the different groups was evaluated by plethysmometry. Proinflammatory cytokines TNF-α and IL-1α were quantified by cytometric bead array (CBA). Results: The effect of phonophoresis of aqueous gel with E. nuda extract on arthritis in rats' paws (a 33% reduction compared with the controls) was the same as that produced by phonophoresis with diclofenac diethylammonium. Ultrasound therapy without phonophoresis produced no significant effect on the 21st day of therapy. There was a significant reduction in TNF-α and IL-1α levels in the group treated with phonophoresis with E. nuda gel (p=0.0042; p=0.0003, respectively). Conclusion: Our results demonstrate the anti-inflammatory effect of phonophoresis with E. nuda gel on cytokines TNF-α, IL-1α and adjuvant-induced arthritis.
机译：背景：由于其他因素，他们的抗炎特性，巴西本土人群使用各种种类的Pouteria（Elaeoluma）。最近在前瞻性药理学研究中鉴定了亚马逊植物Elaeoluma Nuda提取物的抗炎性质。目的：本研究的目的是评估对大鼠佐剂诱导的关节炎的E. NUDA水溶性凝胶提取物的抗炎作用。方法论：关节炎在具有佐剂的路易斯大鼠中诱导。然后每天施用具有E. Nuda凝胶的肾殖者。与用双氯芬酸二乙基铵凝胶和超声疗法获得的那些，结果与结果相比，没有致声营养。用血小影学评估不同组中的关节炎。促炎细胞因子TNF-α和IL-1α通过细胞计数珠阵列（CBA）量化。结果：大鼠爪子中含水凝胶水溶性凝胶的影响（与对照相比33％的减少）与双氯芬酸二乙基铵相同。没有致育育疗法的超声治疗在21天的治疗中没有产生显着影响。用E. nuda凝胶用阳剧蛋白处理的基团TNF-α和IL-1α水平显着降低（p = 0.0042; p = 0.0003）。结论：我们的结果表明，在细胞因子TNF-α，IL-1α和佐剂诱导的关节炎上具有大肠凝胶的抗炎作用。

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  • 来源
    《Cytokine》 |2014年第2期|共5页
  • 作者

    MeriniL.R.; FurtadoS.D.C.; OliveiraM.M.B.D.; CarneiroA.L.B.; BoechatA.L.; BarcellosJ.F.M.;

  • 作者单位

    Postgraduate Program in Basic and Applied Immunology Institute of Biological Sciences Federal;

    Morphology Department Institute of Biological Sciences Federal University of Amazonas Brazil;

    Undergraduate Science Project Morphology Department Institute of Biological Sciences Federal;

    Morphology Department Center for Health Sciences Federal University of Paraíba Brazil;

    Postgraduate Program in Basic and Applied Immunology Institute of Biological Sciences Federal;

    Postgraduate Program in Basic and Applied Immunology Institute of Biological Sciences Federal;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 细胞生物学;
  • 关键词

    Adjuvant-induced arthritis; Elaeoluma nuda; Phonophoresis;

    机译：佐剂诱导的关节炎;Elaeoluma Nuda;致盲营养症;

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