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Spatial cytokine distribution following traumatic injury

机译：创伤后损伤后的空间细胞因子分布

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摘要

Temporal changes in cytokine concentrations following traumatic injuries have been extensively studied. Less is known regarding spatial differences in cytokine concentrations following traumatic injury. The primary aim of this study was to determine the spatial relationship between cytokines and the zone of injury (ZOI). Muscle and vessel tissues obtained from rats subjected to an open femoral fracture were analyzed to determine if spatial cytokine gradients exist that could potentially be used as biomarkers of the ZOI. Samples were collected at 4 time points following fracture from 3 distinct locations: at the fracture site, 1-cm away from the fracture, and from the opposite leg. The concentrations of IL-6, IL-1alpha, IL-1beta, IL-2, GM-CSF, TNF-alpha, and MIP-1alpha were quantified in each sample. Temporally and spatially regulated variations in cytokine concentrations were found. IL-6 showed the most promise as a ZOI bio-marker with statistically different spatial concentrations that were inversely proportional to the distance from the fracture in both tissues. IL-1beta and IL-2 also showed spatial differences in concentration in both tissues, while GM-CSF, MIP-1alpha, and TNF-alpha showed spatial differences in vessel samples. These results demonstrate that spatial cytokine gradients exist following traumatic injury, representing potential biomarkers that may be used to define the ZOI.
机译：采用创伤损伤后细胞因子浓度的时间变化已被广泛研究。关于创伤后损伤后的细胞因子浓度的空间差异较少。本研究的主要目的是确定细胞因子与损伤区（ZOI）之间的空间关系。分析从受开放股骨骨折的大鼠获得的肌肉和血管组织，以确定是否存在可能用作ZOI的生物标志物的空间细胞因子梯度。在3个不同位置裂缝后4个时间点收集样品：在裂缝部位，远离骨折的1厘米，来自相对的腿。在每个样品中量化IL-6，IL-1α，IL-1Beta，IL-2，GM-CSF，TNF-α和MIP-1α和MIP-1α的浓度。发现了发现细胞因子浓度的空间和空间上调的变化。 IL-6显示出最理想的是具有统计学上不同的空间浓度的ZOI生物标记，其与两种组织中的骨折的距离成反比。 IL-1BETA和IL-2还显示出两种组织中浓度的空间差异，而GM-CSF，MIP-1Alpha和TNF-α在血管样品中显示出空间差异。这些结果表明，在创伤性损伤之后存在空间细胞因子梯度，代表可用于定义ZOI的潜在生物标志物。

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