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首页> 外文期刊>Acta veterinaria. >IMMUNIZATION OF PIGS WITH RECOMBINANT PLASMIDS CONTAINING GENES OF UBIQUITINATED p30, p54 AND CD2v PROTEINS OF AFRICAN SWINE FEVER VIRUS
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IMMUNIZATION OF PIGS WITH RECOMBINANT PLASMIDS CONTAINING GENES OF UBIQUITINATED p30, p54 AND CD2v PROTEINS OF AFRICAN SWINE FEVER VIRUS

机译：用含有普遍的P30，P54和非洲猪瘟病病毒的P30，P54和CD2V蛋白的基因的重组质粒免疫猪

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摘要

Three recombinant plasmid constructs, expressing chimeric proteins containing human ubiquitin fused to an ectodomain of one of the potentially protective proteins (p30, p54 and CD2v) of the attenuated MK-200 strain of African swine fever virus (ASFV), were created as potential inductors of specific antiviral cellular immunity. Three-time immunization of pigs with the mixture of these plasmids led to the formation of virus-specific cytotoxic T-lymphocytes (CTL), but did not induce production of virusspecific antibodies. After challenge with the homologous parental virulent ASFV strain M-78 at a dose of 10(3) HAD(50) all five animals (four immunized pigs and one naive) fell between the 4th and 7th days post infection. The obtained results demonstrated that induction of CTL did not protect pigs against challenge with the virulent ASFV. Balanced activation of CTL and antibody-mediated cellular mechanisms should be investigated.
机译：三种重组质粒构建体，表达含有人泛素的嵌合蛋白融合在潜在的保护蛋白（P30，P54和CD2V）中的非洲猪瘟病毒（ASFV）中的潜在保护蛋白（P30，P54和CD2V）之一的突氏植物，作为潜在的电感器 特异性抗病毒细胞免疫。 用这些质粒的混合物对猪的三次免疫导致形成病毒特异性细胞毒性T淋巴细胞（CTL），但没有诱导virusspecific抗体的产生。 在用10（3）（50）含量为10（3）的剂量的同源父母生长的ASFV菌株M-78攻击后，第4天和第7天之间的所有五种动物（四只免疫猪和一个幼稚）下降。 所获得的结果表明CTL的诱导不保护猪与毒力ASFV攻击。 应研究CTL和抗体介导的细胞机制的平衡活化。

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