• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Crystal growth & design >Two Faces of Ciprofloxacin: Investigation of Proton Transfer in Solid State Transformations
【24h】

Two Faces of Ciprofloxacin: Investigation of Proton Transfer in Solid State Transformations

机译：环丙沙星的两个面孔：固态转化中质子转移的研究

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Ciprofloxacin (CIP) can exist in two different forms: the zwitterion and the un-ionized form. While the crystal structure of each has been described independently, the ability of CIP to transform from one form to the other in the solid state has not been described. The crystal structures of unionized and zwitterionic CIP were therefore compared using computational methods, including their packing arrangement, hydrogen bonding, packing energy, intermolecular potentials, and highest occupied molecular orbital/lowest occupied molecular orbital energy gap. The pure amorphous form of CIP has also never been prepared or studied. Ball milling, cryomilling, and spray drying were used in this study to prepare partially and fully amorphous CIP for the first time. The physical characteristics were examined by powder X-ray diffraction, Fourier transform infrared spectroscopy, and differential scanning calorimetry. CIP proved to be very difficult to amorphize, and only spray drying in pure water resulted in a fully amorphous product. It was discovered that while most processing methods resulted in the more stable zwitterionic form of the drug, spray drying in an ethanol/water mixture produced the un-ionized form. The zwitterion was found to convert to the un-ionized form upon heating to its melting point, whereas the reverse transformation occurred when un-ionized CIP was exposed to high humidity. This study thus provides insight
机译：环丙沙星（CIP）可以两种不同形式存在：两性离子和非离子形式。尽管已经分别描述了每种的晶体结构，但是尚未描述CIP在固态下从一种形式转变为另一种形式的能力。因此，使用计算方法比较了工会化和两性离子CIP的晶体结构，包括它们的堆积排列，氢键，堆积能量，分子间电势和最高占据的分子轨道/最低占据的分子轨道能隙。从未制备或研究过纯CIP的无定形形式。在这项研究中，采用球磨，低温研磨和喷雾干燥首次制备了部分和完全非晶态的CIP。通过粉末X射线衍射，傅里叶变换红外光谱和差示扫描量热法检查了物理特性。 CIP被证明很难非晶化，只有在纯水中喷雾干燥才能得到完全非晶的产品。已发现，尽管大多数加工方法可产生更稳定的两性离子形式的药物，但在乙醇/水混合物中喷雾干燥可产生未电离的形式。发现两性离子在加热到其熔点时会转变为非电离形式，而当未电离的CIP暴露于高湿度时会发生反向转化。因此，这项研究提供了见识

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号