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首页> 外文期刊>Advances in physiology education >Teaching a changing paradigm in physiology: a historical perspective on gut interstitial cells
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Teaching a changing paradigm in physiology: a historical perspective on gut interstitial cells

机译：在生理学中教学改变范式：肠道间质细胞的历史视角

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摘要

The study and teaching of gastrointestinal (GI) physiology necessitates an understanding of the cellular basis of contractile and electrical coupling behaviors in the muscle layers that comprise the gut wall. Our knowledge of the cellular origin of GI motility has drastically changed over the last 100 yr. While the pacing and coordination of GI contraction was once thought to be solely attributable to smooth muscle cells, it is now widely accepted that the motility patterns observed in the GI tract exist as a result of a multicellular system, consisting of not only smooth muscle cells but also enteric neurons and distinct populations of specialized interstitial cells that all work in concert to ensure proper GI functions. In this historical perspective, we focus on the emerging role of interstitial cells in GI motility and examine the key discoveries and experiments that led to a major shift in a paradigm of GI physiology regarding the role of interstitial cells in modulating GI contractile patterns. A review of these now classic experiments and papers will enable students and educators to fully appreciate the complex, multicellular nature of GI muscles as well as impart lessons on how shifting paradigms in physiology are fueled by new technologies that lead to new emerging discoveries.
机译：胃肠道（GI）生理学的研究和教学需要了解包含肠壁的肌肉层中收缩和电耦合行为的细胞基础。我们对胃肠杆菌的细胞来源的了解在过去100年的最后100岁上急剧发生变化。虽然GI收缩的起搏和协调曾经认为仅归因于平滑的肌肉细胞，但现在普遍认为，由于多细胞系统，在GI沟中观察到的运动模式，不仅包括平滑肌细胞而且还有肠道神经元和不同的专业间质细胞的群体，所有工作都在音乐会上工作，以确保适当的GI功能。在这一历史的角度来看，我们专注于胃肠杆菌间质细胞的新兴作用，并研究了导致在调节Gi收缩模式中的间质细胞的胃肠杆菌的范例的主要发现和实验。现在对这些经典实验和论文的审查将使学生和教育工作者能够充分欣赏到GI肌肉的复杂，多细胞性质，以及对生理学中的转移范例如何通过导致新的新兴发现的新技术来推动课程。

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