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首页> 外文期刊>AIDS Research and Human Retroviruses >Frequent Detection of Antiretroviral Drug Resistance in HIV-1-Infected Orphaned Children Followed at a Donor-Funded Rural Pediatric Clinic in Dodoma, Tanzania
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Frequent Detection of Antiretroviral Drug Resistance in HIV-1-Infected Orphaned Children Followed at a Donor-Funded Rural Pediatric Clinic in Dodoma, Tanzania

机译：常常检测抗逆转录病毒耐药性在HIV-1感染的孤儿儿童中，然后在Dodoma，坦桑尼亚的捐助国农牧诊所

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A total of 81 HIV-1 protease (PR) and reverse transcriptase (RT) sequences were obtained from 46 drug-naive and 35 pretreated individual HIV-1-infected orphaned children followed at a donor-funded rural pediatric clinic in Dodoma, Tanzania. PR and RT sequencing was performed by home-brew technology on 70 plasma samples and 11 dried blood spot specimens. Nucleoside RT inhibitor (NRTI) resistance mutations were detected in 2.2% of drug-naive and 82.9% of pretreated children. Nonnucleoside RT inhibitor (NNRTI) resistance mutations were detected in 69.6% of drug-naive and 91.4% of pretreated children. Resistance to protease inhibitors was rare (8.6% in pretreated children). Based on few complete treatment records, only around 20% of the treated children had undetectable plasma HIV-1 RNA. The rate of NRTI and NNRTI resistance in this donor-funded rural pediatric clinic was high and appeared to limit virological response to treatment.
机译：从46个药物 - 幼稚和35个预处理的个体HIV-1感染的孤儿儿童获得了总共81个HIV-1蛋白酶（PR）和逆转录酶（RT）序列，然后在坦桑尼亚Dodoma的捐助者资助的农村小儿科诊所。 PR和RT测序由70种血浆样品和11个干血斑样品进行家用 - Brew Technology。 在2.2％的药物 - 幼稚和82.9％的预处理儿童中检测到核苷RT抑制剂（NRTI）抗性突变。 在69.6％的药物 - 幼稚和91.4％的预处理儿童中检测壬核苷RT抑制剂（NNRTI）抗性突变。 抗蛋白酶抑制剂的耐稀有（预处理儿童8.6％）。 根据少数完整的治疗记录，只有约20％的治疗儿童具有未检测到的血浆HIV-1 RNA。 该捐助国资助的农田诊所的NRTI和NNRTI抗性的速率高，似乎限制了对治疗的病毒学反应。

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